In vitro antimicrobial susceptibility to combinations of drugs of bacteria from carious and endodontic lesions of human deciduous teeth

T. Sato, E. Hoshino, H. Uematsu, T. Noda

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)

Abstract

The purpose of this study was to clarify the antibacterial efficacy of mixed antibacterial drugs on bacteria of carious and endodontic lesions of human deciduous teeth in vitro. The antibacterial drugs used in this study were mixtures of ciprofloxacin, metronidazole, plus a third antibiotic: amoxicillin, cefaclor, cefroxadine, fosfomycin or rokitamycin. Samples taken from carious dentin (17 cases) and infected pulpal tissues (14 cases) were cultured on control plates and plates containing the mixed drugs. No bacteria were recovered in the presence of any combination of the mixture of the drugs (100μg each/ml), and the bacterial growth occurred on control plates (101 to 107 colony‐forming units), indicating that the mixed drugs inhibit the growth of bacteria in the samples. When carious and endodontic lesions on split surfaces of freshly extracted teeth were covered overnight with α‐tricalcium phosphate cement containing a mixture of ciprofloxacin, metronidazole and cefaclor (1% each; 5 cases), no bacteria were recovered from the lesions. No bacteria were recovered from carious and endodontic lesions when these lesions were immersed in a solution of the mixture (200 μg each/ml; 5 cases). These findings indicate that carious and endodontic lesions can be sterilized by the mixed drugs in situ.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalOral Microbiology and Immunology
Volume8
Issue number3
DOIs
Publication statusPublished - 1993 Jun

Keywords

  • amoxicillin
  • caries
  • cefaclor
  • cefroxadine
  • ciprofloxacin
  • deciduous teeth
  • fosfomycin
  • metronidazole
  • rokitamycin

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Dentistry(all)
  • Microbiology (medical)

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