In vitro antimicrobial activity of hapa-B

Seiichi Aonuma, Reiko Ono, Noriko Otani, Kikuo Onuma, Akira Watanabe, Masako Sasaki, Kotaro Oizumi, Kiyoshi Konno

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    In vitro antimicrobial activity of hapa-B, a new derivative of aminoglycoside, was examined by a broth dilution method with Dynatech MIC 2000 system. The minimum inhibitory concentrations of hapa-B were compared with those of gentamicin (GM) and amikacin (AMK) against the following 120 strains (each 20 strains) of clinical isolates of 5. aureus, E. coli, K. pneumoniae, S. marcescens, Enterobacter spieces and P. aeruginosa. Against S. aureus, E. coli, K. pneumoniae and S. marcescens, hapa-B was shown to be less active than GM, but more active than AMK. hapa-B was as active as AMK, although less active than GM, against Enterobacter spieces and P. aeruginosa.

    Original languageEnglish
    Pages (from-to)149-157
    Number of pages9
    Publication statusPublished - 1985 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology


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