In vitro antimicrobial activity of ceftazidime and its therapeutic efficacy in respiratory tract infections

Seiichi Aonuma, Akira Watanabe, Kikuo Onuma, Masako Sasaki, Kotaro Oizumi, Kiyoshi Konno

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In vitro antimicrobial activity of ceftazidime (CAZ, SN401), a new derivative of cephalosporin, was examined by a broth dilution method with Dynatech MIC 2000 system. Also, the therapeutic efficacy of CAZ was evaluated in patients with respiratory tract infections. The minimum inhibitory concentrations (MICs) of CAZ were compared with those of cefazolin (CEZ), cefmetazole (CMZ), ceftizoxime (CZX), cefsulodin (CFS), piperacillin (PIPC) and sulbenicillin (SBPC), against the following 100 strains (each 20 strains) of clinical isolates of S. aureus, E.coli, K. pneumoniae, S. marcescens and P. aeruginosa. Against S. aureus, CAZ was shown to be less active than CEZ, CMZ and CZX. In contrast, CAZ was far more active than CEZ and CMZ, although slightly less active than CZX, against E.coli, K. pneumoniae and S. marcescens, and more active than CZX, CFS, PIPC and SBPC against P. aeruginosa. Eight patients were treated with intravenous drip infusion of CAZ at the doses of 1∼2 g twice a day. Two patients were excluded from the evaluation of the therapeutic efficacy of CAZ because one died from rapid progress of lung cancer shortly after start of the CAZ treatment of secondary infection and the other, who was a suspected case of lung abscess, showed no evidence of secondary infection and was diagnosed as the case of lung cancer. In the remaining six patients, response to the treatment with CAZ was good in 2 and fair in 2 and poor in the other 2. Neither undesirable symptoms nor abnormal laboratory findings were observed during or after the administration of CAZ.

    Original languageEnglish
    Pages (from-to)228-234
    Number of pages7
    JournalChemotherapy
    Volume31
    Issue numberSupplement
    DOIs
    Publication statusPublished - 1983 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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