In vitro antimicrobial activity of cefroxadine (CGP-9000) and its therapeutic effects on respiratory and urinary tract infections

Akira Watanabe, Seiichi Aonuma, Kikuo Ohnuma, Masako Sasaki, Kohtaro Oizumi, Kiyoshi Konno

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cefroxadine (CGP-9000, CXD) is a new semisynthetic derivative of cephalosporin designed for oral use. Its antimicrobial activity against bacterial isolates from clinical specimens was determined by the standard method of the Japanese Society for Chemotherapy. CXD was found to be active against a variety of gram-positive and gram-negative bacteria. The minimum inhibitory concentrations (MICs) of the drug against patient strains of Staphylococcus aureus were slightly higher than those of Cephalexin (CEX) and considerably higher than those of Cefazolin (CEZ). No substantial difference was found between the levels of MICs of CXD and those of CEX against clinical isolates of E. coli, and CEZ was most active to these strains among the three drugs. Ten of 18 strains of Klebsiella pneumoniae were inhibited at the concentrations of 6.25 μg/ml or less of CXD and CEX. One third of the strains were refractory to 25 Mg/ml or more of the two drugs. All four strains of Enterobacter tested were not susceptible to CXD, CEX and CEZ. Seven patients with upper and lower respiratory tract infections and two patients with urinary tract infections were treated by oral administration of 1 to 1.5 gram a day of CXD. All these patients responded quite well to the treatment by the drug. However, it must be taken into consideration that the infections in these patients who were chosen for the treatment by oral administration were relatively mild or moderate in severity. None of undesirable symptoms and signs developed in these patients during the treatment with the drug and also no abnormality in labolatory findings was observed during or after the drug administration.

    Original languageEnglish
    Pages (from-to)158-164
    Number of pages7
    JournalChemotherapy
    Volume28
    Issue number7
    DOIs
    Publication statusPublished - 1980

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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