In vitro antimicrobial activity of cefodizime (THR-221) and clinical evaluation in respiratory tract infections

Seiichi Aonuma, Yutaka Tokue, Naoto Kitamura, Yoshihiro Honda, Reiko Ono, Akira Watanabe, Masako Sasaki, Kotaro Oizumi, Kiyoshi Konno, Kosaku Nagai

    Research output: Contribution to journalArticle

    Abstract

    In vitro antimicrobial activity of cefodizime (THR-221), a new cephalosporin, was examined by broth-dilution method using the MIC-2000 system. The minimum inhibitory concentrations (MICs) for THR-221 against 170 clinical isolates were compared with those for cefotaxime (CTX), cefoperazone (CPZ) and Iatamoxef (LMOX). Against all isolates tested, THR-221 was less active than CTX. THR-221 was more active than LMOX against S. aureus and Proteus spp., and less active than CPZ against S. aureus, E. cloacae and P. aeruginosa. THR-221 was administered to 18 patients with respiratory tract infection by drip infusion. Clinical response was excellent in 1, good in 12, fair in 1 and poor in 2; 2 cases were not evaluable. Adverse reactions and abnormal laboratory levels were: skin rash, urticaria, diarrhea, eosinophilia and thrombocytopenia in one case each.

    Original languageEnglish
    Pages (from-to)329-338
    Number of pages10
    JournalChemotherapy
    Volume36
    DOIs
    Publication statusPublished - 1988 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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  • Cite this

    Aonuma, S., Tokue, Y., Kitamura, N., Honda, Y., Ono, R., Watanabe, A., Sasaki, M., Oizumi, K., Konno, K., & Nagai, K. (1988). In vitro antimicrobial activity of cefodizime (THR-221) and clinical evaluation in respiratory tract infections. Chemotherapy, 36, 329-338. https://doi.org/10.11250/chemotherapy1953.36.Supplement5_329