In vitro antimicrobial activities and therapeutic effects on respiratory tract infections of cefoperazone (T-1551)

Seiichi Aonuma, Akira Watanabe, Kikuo Onuma, Masako Sasaki, Kotaro Oizumi, Kiyoshi Konno

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    From the results of in vitro tests a new semi-synthetic cephalosporin derivative, cefoperazone (CPZ, T-1551), was shown to be especially active against patient strains of gram-negative species, such as Pseudomonas aeruginosa, Klebsiella pneumoniae, E. coli and Enterobacter sp. Twenty two patients of respiratory tract infections were treated by intravenous drip infusion of one to two grams of CPZ twice a day and in most of them a positive response was obtained. No undesirable symptom was observed in them, except for drug fever in a patient and diarrhea in the other. A slight degree elevation of serum transaminases and alkaline phosphatase was seen in a few cases during the course of the treatment with the drug but the deteriorations in laboratory findings were transient and the values returned to normal levels after with drawal of the agent.

    Original languageEnglish
    Pages (from-to)332-340
    Number of pages9
    JournalChemotherapy
    Volume28
    Issue number7
    DOIs
    Publication statusPublished - 1980 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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