In vitro antimicrobial activities and therapeutic effect of azthreonam (SQ 26, 776) on respiratory tract infections

Kikuo Onuma, Seiichi Aonuma, Akira Watanabe, Masako Sasaki, Kotaro Oizumi, Kiyoshi Konno

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The MICs of Azthreonam(SQ 26, 776)against 121 bacterial strains from patientsș sputa were compared with those of Cefazolin, Cefmetazole, Ceftizoxime and Latamoxef on Enterobacteriaceae and with those of Piperacillin and Cefsulodin on Pseudomonas aeruginosa, and the efficacy of Azthreonam in the treatment of two patients with pneumonia which had not been cured by some other antibiotics was evaluated. The results of in vitro tests revealed that Azthreonam was as highly active against Escherichia coli, Klebsiella sp., Enterobacter sp. and Serratia sp. as Ceftizoxime and was more active than Cefazolin, Cefmetazole and Latamoxef. The antipseudomonal activity of Azthreonam was less than that of Cefsulodin but more than that of Piperacillin. Two grams of Azthreonam per day was given to the patients by intravenous drip infusion. Clinical response to the treatment was good and infiltrative shadows on the chest X-ray films disappeared in both patients. In one patient, drug fever occurred during the treatment, but body temperature became normal soon after cessation of the drug. No other side effects were observed.

    Original languageEnglish
    Pages (from-to)285-288
    Number of pages4
    JournalChemotherapy
    Volume33
    DOIs
    Publication statusPublished - 1985 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

    Fingerprint Dive into the research topics of 'In vitro antimicrobial activities and therapeutic effect of azthreonam (SQ 26, 776) on respiratory tract infections'. Together they form a unique fingerprint.

    Cite this