In vitro antimicrobial activities and clinical effects of pc-904 on respiratory tract infections

Akira Watanabe, Masako Sasaki, Kotaro Oizumi, Kiyoshi Konno, Izumi Hayashi, Kiichi Kaishio

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Antimicrobial activities and therapeutic effects of PC-904, a new penicillin derivative, were studied and the following results were obtained. The minimum inhibitory concentrations of PC-904 against 17 clinical isolates of Klebsiella pneumoniae ranged from 25 ug/ml to 1600 ug/ml, but it was shown that PC-904 was more active against those strains than CBPC and SBPC in a degree of 3 or 4 fold dilutions. The susceptibilitis of those strains to CEZ were nearly equal to those to PC-904. The growth of the clinically isolated strains of Pseudomonas aeruginosa was inhibited at 4 to 8 fold lower concentration of PC-904 than those of CBPC and SBPC. Nineteen cases with respiratory tract infection, a case with biliary and 3 cases with urinary tract infections were treated with PC-904. 1g or 2g of the drug was administered by drip infusion twice a day for a period of 1 to 3 weeks. An excellent response was obtained in 6 cases, a good or moderate therapeutic effect was observed in 8 and 5 cases respectively, out of total 19 cases with respiratory tract infections. In all 4 cases with biliary or urinary tract infections, the response was excellent. Adverse effects were observed in 6 cases out of total 23 cases treated with PC-904, including a case with eruption, a case with drug fever showing transient leukopenia, 2 cases with symptoms such as fever and myalgia etc. probably due to hypersensitivity to the drug, and 2 cases with slightly elevated values of transaminases or BUN. In all of these cases, symptoms and signs of adverse effects subsided and deteriorated laboratory findings became normal shortly after the withdrawal of the drug.

    Original languageEnglish
    Pages (from-to)211-218
    Number of pages8
    JournalChemotherapy
    Volume26
    DOIs
    Publication statusPublished - 1978 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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