In vitro antibacterial activity of bay o 9867 and its therapeutic efficacy on respiratory tract and urinary tract infections

Seiichi Aonuma, Reiko Ono, Noriko Otani, Kikuo Onuma, Akira Watanabe, Masako Sasaki, Kotaro Oizumi, Kiyoshi Konno

    Research output: Contribution to journalArticle

    Abstract

    BAY o 9867, a new pyridone carboxylic acid derivative, has been synthesized by Bayer AG, Wuppertal, West Germany. It was shown that this new agent possessed a broad antimicrobial spectrum covering gram-positive cocci and gram-negative bacilli. Minimal inhibitory concentrations of the agent against each 20 clinical isolates of S. aureus, E. coli, K. pneumoniae, S. tnarcescens, Enterobacter and P. aeruginosa were determined by use of Dynatech MIC 2000 system. At a concentration of 0.78 μg/ml, BAY o 9867 inhibited 100, 90, 95 and 95 percent of the strains of S. aureus, E. coli, Enterobacter and P. aeruginosa, respectively, and at a concentration of 0.1 μg/ml, this agent inhibited 100 and 90 percent of the strains of K. pneumoniae and S. marcescens, respectively. Six patients suffering from respiratory tract infections and a patient of urinary tract infection received orally 600 mg of BAY o 9867 a day. Each one patient showed an excellent and a good clinical response, while one other patient responded only fairly and other four poorly. No undesirable symptoms and signs due to administration of the drug was observed. In one case, slight elevation of GOT and GPT was observed after administration of the agent.

    Original languageEnglish
    Pages (from-to)226-232
    Number of pages7
    JournalChemotherapy
    Volume33
    DOIs
    Publication statusPublished - 1985 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology

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