In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent

Yoshimi Niwano, Naoki Kuzuhara, Hiroki Kodama, Masanori Yoshida, Tsuneo Miyazaki, Hideyo Yamaguchi

Research output: Contribution to journalComment/debatepeer-review

51 Citations (Scopus)

Abstract

In vitro and in vivo antidermatophyte activities of NND-502, a new imidazole antimycotic agent, were compared with those of two existing antifungal agents, lanoconazole and terbinafine. NND-502 exhibited strong in vitro antifungal activity against Trichophyton spp.; its MIC was 1 to 4 times lower than that of lanoconazole or terbinafine. In an in vivo study with a guinea pig model of tinea pedis, 7-day topical treatment with a 0.5% solution of NND-502 (dissolved in polyethylene glycol 400) was more effective than that with a 0.5% solution of either lanoconazole or terbinafine for eradicating fungi from the infected feet. When the duration of treatment was shortened to 3 days, a topical 1% solution of NND-502 achieved a complete mycological cure, while topical 1% solutions of lanoconazole and terbinafine did not.

Original languageEnglish
Pages (from-to)967-970
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume42
Issue number4
DOIs
Publication statusPublished - 1998 Apr

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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