In situ Raman study of the instant spectral changes observed in a pancreatic tumor tissue in living and dead model mice

Toshiaki Suzuki; Y. Hattori; Takashi Katagiri; Hiroki Mitsuoka; Atsushi Kanno; Kennichi Satoh; Toru Asakura; Toru Shimosegawa; Hidetoshi Sato

doi:10.1117/12.764129

In situ Raman study of the instant spectral changes observed in a pancreatic tumor tissue in living and dead model mice

Toshiaki Suzuki, Y. Hattori, Takashi Katagiri, Hiroki Mitsuoka, Atsushi Kanno, Kennichi Satoh, Toru Asakura, Toru Shimosegawa, Hidetoshi Sato

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Living pancreatic cancer tissues grown subcutaneously in nude mice are studied by in vivo microscope Raman spectroscopy. Comparing the spectra of living pancreatic cancer tissue to that of the dead same tissue, it is found that they are different each other. In the subtraction spectrum, Raman bands observed at 937, 1251, 1447 and 1671 cm^-1 are appeared in negative direction and those observed at 966 and 1045 cm^-1 are appeared in positive direction. The results strongly suggest that the spectral changes reflect the protein conformational changes in the tumor tissue with death of the host animal. The present result demonstrates the importance of in vivo, real time studies of biomedical tissues using Raman spectroscopy.

Original language	English
Title of host publication	Biomedical Optical Spectroscopy
DOIs	https://doi.org/10.1117/12.764129
Publication status	Published - 2008
Event	Biomedical Optical Spectroscopy - San Jose, CA, United States Duration: 2008 Jan 19 → 2008 Jan 23

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6853
ISSN (Print)	1605-7422

Other

Other	Biomedical Optical Spectroscopy
Country	United States
City	San Jose, CA
Period	08/1/19 → 08/1/23

Keywords

In vivo
Living experiment
Pancreatic cancer tissue
Raman spectroscopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.764129

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Suzuki, T., Hattori, Y., Katagiri, T., Mitsuoka, H., Kanno, A., Satoh, K., Asakura, T., Shimosegawa, T., & Sato, H. (2008). In situ Raman study of the instant spectral changes observed in a pancreatic tumor tissue in living and dead model mice. In Biomedical Optical Spectroscopy [685314] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6853). https://doi.org/10.1117/12.764129

In situ Raman study of the instant spectral changes observed in a pancreatic tumor tissue in living and dead model mice. / Suzuki, Toshiaki; Hattori, Y.; Katagiri, Takashi; Mitsuoka, Hiroki; Kanno, Atsushi; Satoh, Kennichi; Asakura, Toru; Shimosegawa, Toru; Sato, Hidetoshi.

Biomedical Optical Spectroscopy. 2008. 685314 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6853).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Suzuki, T, Hattori, Y, Katagiri, T, Mitsuoka, H, Kanno, A, Satoh, K, Asakura, T, Shimosegawa, T & Sato, H 2008, In situ Raman study of the instant spectral changes observed in a pancreatic tumor tissue in living and dead model mice. in Biomedical Optical Spectroscopy., 685314, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6853, Biomedical Optical Spectroscopy, San Jose, CA, United States, 08/1/19. https://doi.org/10.1117/12.764129

Suzuki, Toshiaki ; Hattori, Y. ; Katagiri, Takashi ; Mitsuoka, Hiroki ; Kanno, Atsushi ; Satoh, Kennichi ; Asakura, Toru ; Shimosegawa, Toru ; Sato, Hidetoshi. / In situ Raman study of the instant spectral changes observed in a pancreatic tumor tissue in living and dead model mice. Biomedical Optical Spectroscopy. 2008. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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abstract = "Living pancreatic cancer tissues grown subcutaneously in nude mice are studied by in vivo microscope Raman spectroscopy. Comparing the spectra of living pancreatic cancer tissue to that of the dead same tissue, it is found that they are different each other. In the subtraction spectrum, Raman bands observed at 937, 1251, 1447 and 1671 cm-1 are appeared in negative direction and those observed at 966 and 1045 cm-1 are appeared in positive direction. The results strongly suggest that the spectral changes reflect the protein conformational changes in the tumor tissue with death of the host animal. The present result demonstrates the importance of in vivo, real time studies of biomedical tissues using Raman spectroscopy.",

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AU - Kanno, Atsushi

AU - Satoh, Kennichi

AU - Asakura, Toru

AU - Shimosegawa, Toru

AU - Sato, Hidetoshi

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AB - Living pancreatic cancer tissues grown subcutaneously in nude mice are studied by in vivo microscope Raman spectroscopy. Comparing the spectra of living pancreatic cancer tissue to that of the dead same tissue, it is found that they are different each other. In the subtraction spectrum, Raman bands observed at 937, 1251, 1447 and 1671 cm-1 are appeared in negative direction and those observed at 966 and 1045 cm-1 are appeared in positive direction. The results strongly suggest that the spectral changes reflect the protein conformational changes in the tumor tissue with death of the host animal. The present result demonstrates the importance of in vivo, real time studies of biomedical tissues using Raman spectroscopy.

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