In situ Raman study of the instant spectral changes observed in a pancreatic tumor tissue in living and dead model mice

Toshiaki Suzuki, Y. Hattori, Takashi Katagiri, Hiroki Mitsuoka, Atsushi Kanno, Kennichi Satoh, Toru Asakura, Toru Shimosegawa, Hidetoshi Sato

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Living pancreatic cancer tissues grown subcutaneously in nude mice are studied by in vivo microscope Raman spectroscopy. Comparing the spectra of living pancreatic cancer tissue to that of the dead same tissue, it is found that they are different each other. In the subtraction spectrum, Raman bands observed at 937, 1251, 1447 and 1671 cm-1 are appeared in negative direction and those observed at 966 and 1045 cm-1 are appeared in positive direction. The results strongly suggest that the spectral changes reflect the protein conformational changes in the tumor tissue with death of the host animal. The present result demonstrates the importance of in vivo, real time studies of biomedical tissues using Raman spectroscopy.

Original languageEnglish
Title of host publicationBiomedical Optical Spectroscopy
DOIs
Publication statusPublished - 2008
EventBiomedical Optical Spectroscopy - San Jose, CA, United States
Duration: 2008 Jan 192008 Jan 23

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6853
ISSN (Print)1605-7422

Other

OtherBiomedical Optical Spectroscopy
CountryUnited States
CitySan Jose, CA
Period08/1/1908/1/23

Keywords

  • In vivo
  • Living experiment
  • Pancreatic cancer tissue
  • Raman spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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