In situ production of sex steroids in human breast carcinoma

Takashi Suzuki, Yasuhiro Miki, Takuya Moriya, Jun Ichi Akahira, Hisashi Hirakawa, Noriaki Ohuchi, Hironobu Sasano

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)

Abstract

It is well known that sex steroids are closely involved in the growth of human breast carcinomas, and the great majority of breast carcinomas express sex steroid receptors. In particular, recent studies have demonstrated that estrogens and androgens are locally produced and act in breast carcinoma tissues without release into plasma. Blockade of intratumoral estrogen production potentially leads to an improvement in the prognosis of invasive breast carcinoma patients, and, therefore, it is important to obtain a better understanding of sex steroid-producing enzymes in breast carcinoma. In this review, we summarize recent studies on tissue concentration of sex steroids and expression of enzymes related to intratumoral production of estrogens [aromatase, steroid sulfatase (STS), and 17β-hydroxysteroid dehydrogenase type 1 (17βHSD1)], and androgens (17βHSD5 and 5α-reductase) in invasive and in situ (noninvasive) breast carcinomas, and discuss the significance of intratumoral production of sex steroids in breast carcinoma.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalMedical Molecular Morphology
Volume40
Issue number3
DOIs
Publication statusPublished - 2007 Sep 1

Keywords

  • Androgen
  • Aromatase
  • Breast cancer
  • DCIS
  • Estrogen
  • Sex steroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology

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