In situ control of cellular growth and migration on substrates using microelectrodes

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74 Citations (Scopus)

Abstract

We describe an electrochemical method to direct the growth and migration of mammalian cells on a substrate during cultivation in situ. Exposing the albumin-coated substrate to an oxidizing agent, hypobromous acid, electrochemically generated at the tip of the scanning microelectrode, locally switched the substrate from cytophobic to cell-adhesive. This transformation generated the formation of cellular micropatterns. Since the concentration of the oxidizing agent required for the surface processing did not cause significant damage to the cell cultures, we were able to direct in situ cellular proliferation and migration by drawing adhesive micropatterns over the preexisting cellular pattern.

Original languageEnglish
Pages (from-to)15026-15027
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number46
DOIs
Publication statusPublished - 2004 Nov 24

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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