TY - GEN
T1 - In silico simulation of epidermal growth factor signaling in prostate cancer cells
AU - Nakakuki, Takashi
AU - Ide, Kaori
AU - Yumoto, Noriko
AU - Nagashima, Takeshi
AU - Hatakeyama, Mariko
PY - 2007/12/1
Y1 - 2007/12/1
N2 - The epidermal growth factor receptor (EGFR) and its signaling pathways are closely involved in the development and progression of prostate cancer. To understand the EGF-stimulated signaling pathways in prostate cancer cells, we constructed a mathematical model of EGF receptor signaling in PC3 cells based on the experimental data. The model was described by twenty-seven ordinary differential equations, and all parameters were estimated by genetic algorithm. The validity of the model was confirmed with time-course western blot data, showing that the model could successfully reproduce all experimental results.
AB - The epidermal growth factor receptor (EGFR) and its signaling pathways are closely involved in the development and progression of prostate cancer. To understand the EGF-stimulated signaling pathways in prostate cancer cells, we constructed a mathematical model of EGF receptor signaling in PC3 cells based on the experimental data. The model was described by twenty-seven ordinary differential equations, and all parameters were estimated by genetic algorithm. The validity of the model was confirmed with time-course western blot data, showing that the model could successfully reproduce all experimental results.
UR - http://www.scopus.com/inward/record.url?scp=47049086814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47049086814&partnerID=8YFLogxK
U2 - 10.1109/GENSIPS.2007.4365841
DO - 10.1109/GENSIPS.2007.4365841
M3 - Conference contribution
AN - SCOPUS:47049086814
SN - 1424409993
SN - 9781424409990
T3 - GENSIPS'07 - 5th IEEE International Workshop on Genomic Signal Processing and Statistics
BT - 5th IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'07
T2 - 5th IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'07
Y2 - 10 June 2007 through 12 June 2007
ER -