In-Hospital Complications After Surgery in Elderly Patients with Asymptomatic or Minor Symptom Meningioma: A Nationwide Registry Study

Fusao Ikawa, Naoyuki Isobe, Nobuaki Michihata, Soichi Oya, Kenji Ohata, Kiyoshi Saito, Kazunari Yoshida, Kiyohide Fushimi, Hideo Yasunaga, Teiji Tominaga, Kaoru Kurisu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Asymptomatic or minor symptom meningiomas (AMSMs) in the elderly are incidental findings, with no consensus reached on the optimal management strategy. In the present study, we aimed to determine the surgical risk factors for elderly patients with AMSMs using a nationwide registry database in Japan. Methods: We identified patients with surgically treated AMSMs using the Diagnosis Procedure Combination database from 2010 to 2015 and reviewed the medical records for age (<65 years; pre-elderly, 65–74 years; and elderly, ≥75 years), sex, Barthel index (BI) score, medical history, tumor location, and complications. An AMSM was defined by a BI score of 100 points at admission. The risk factors for all stroke complications, BI deterioration at discharge, and in-hospital mortality were determined using multivariate logistic regression analyses. Results: From a total of 10,535 patients with meningioma, 6628 were included. Advanced age was a significant risk factor (odds ratio, 3.54; 95% confidence interval, 2.80–4.46) for BI deterioration but not for all-stroke complications or in-hospital mortality. Midline and posterior fossa tumors, diabetes mellitus, and chronic heart disease were significant risk factors for in-hospital mortality. Conclusions: For elderly patients with surgically treated AMSMs, advanced age was a prominent risk factor for functional decline at discharge. Our study identified several factors that should be evaluated before proceeding with surgery for AMSMs in elderly and pre-elderly patients. These findings could, not only improve decision-making among clinicians treating patients with AMSMs, but also help in predicting the results of surgery for elderly patients with AMSMs.

Original languageEnglish
Pages (from-to)e459-e470
JournalWorld Neurosurgery
Volume148
DOIs
Publication statusPublished - 2021 Apr

Keywords

  • Aged
  • Asymptomatic
  • Database
  • Meningioma
  • Risk factors
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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