Improving proton relaxivity of dendritic MRI contrast agents by rigid silsesquioxane core

Kazuo Tanaka, Narufumi Kltamura, Kensuke Naka, Masahito Morita, Toshiro Inubushi, Moeko Chujo, Masaya Nagao, Yoshiki Chujo

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

We report that the cubic octameric polyhedral oligomeric silsesquioxanes (POSS)-core dendrimers, novel gadolinium (Gd) 1 chelators, enhanced the proton relaxivity to Gd3+. The stability of the Gd complex with POSS(G1.5) was similar to those of DOTA and DTPA. From the MTT assay with the primary hepatocytes, the cytotoxicity of [Gd2POSS(G1.5)]2- showed lower than that of the [Gd(DOTA)]- complex. The detection limits were approximately 100-fold improved than those of DOTA and DTPA-Gd complexes in the MR images.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalPolymer Journal
Volume41
Issue number4
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Contrast agent
  • Dendrimer
  • Gadolinium
  • MRI
  • POSS
  • Silsesquioxane

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry

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