The 48,XXYY syndrome is a form of hypergonadotropic hypogonadism, characterized by tall statures, aggressive behavior, mental retardation, and stasis changes reflecting vascular insufficiency. We report a 25-year-old male with this syndrome showing a peripheral neuropathy and stasis dermatitis which were both reversed by administration of testosterone. Electrophysiologic studies, plethysmography, and thermography indicated that this treatment improved nerve conductivity and peripheral circulation. We postulate that in 48,XXYY syndrome a decrease in testosterone may result in peripheral neuropathy via nerve ischemia.
|Number of pages||6|
|Journal||Tokai Journal of Experimental and Clinical Medicine|
|Publication status||Published - 2000 Jun 1|
- 48,XXYY syndrome
- Peripheral neuropathy
ASJC Scopus subject areas