Improvement of Action Myoclonus in a Patient with Dentatorubral-Pallidoluysian Atrophy by Piracetam

Mieko Hirose; Hiroyuki Yokoyama; Rie Noguchi; Kazuhiro Haginoya; Masashi Aoki; Kazuie Iinuma

Improvement of Action Myoclonus in a Patient with Dentatorubral-Pallidoluysian Atrophy by Piracetam

Mieko Hirose, Hiroyuki Yokoyama, Rie Noguchi, Kazuhiro Haginoya, Masashi Aoki, Kazuie Iinuma

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We report a 13-year-old girl with dentatorubal-pallidoluysian atrophy (DRPLA), presenting clinically as progressive myoclonic epilepsy. The action myoclonus, which severely impaired her daily life, was markedly improved by administration of piracetam, a drug reportedly useful for myoclonus of cortical origin. In our case, piracetam effectively suppressed severe subcortical myoclonus of DRPLA, suggesting that the drug may be useful in the treatment of both cortical, and subcortical myoclonus.

Original language	English
Pages (from-to)	75-79
Number of pages	5
Journal	No To Hattatsu
Volume	36
Issue number	1
Publication status	Published - 2004

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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title = "Improvement of Action Myoclonus in a Patient with Dentatorubral-Pallidoluysian Atrophy by Piracetam",

abstract = "We report a 13-year-old girl with dentatorubal-pallidoluysian atrophy (DRPLA), presenting clinically as progressive myoclonic epilepsy. The action myoclonus, which severely impaired her daily life, was markedly improved by administration of piracetam, a drug reportedly useful for myoclonus of cortical origin. In our case, piracetam effectively suppressed severe subcortical myoclonus of DRPLA, suggesting that the drug may be useful in the treatment of both cortical, and subcortical myoclonus.",

author = "Mieko Hirose and Hiroyuki Yokoyama and Rie Noguchi and Kazuhiro Haginoya and Masashi Aoki and Kazuie Iinuma",

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AU - Hirose, Mieko

AU - Yokoyama, Hiroyuki

AU - Noguchi, Rie

AU - Haginoya, Kazuhiro

AU - Aoki, Masashi

AU - Iinuma, Kazuie

PY - 2004

Y1 - 2004

N2 - We report a 13-year-old girl with dentatorubal-pallidoluysian atrophy (DRPLA), presenting clinically as progressive myoclonic epilepsy. The action myoclonus, which severely impaired her daily life, was markedly improved by administration of piracetam, a drug reportedly useful for myoclonus of cortical origin. In our case, piracetam effectively suppressed severe subcortical myoclonus of DRPLA, suggesting that the drug may be useful in the treatment of both cortical, and subcortical myoclonus.

AB - We report a 13-year-old girl with dentatorubal-pallidoluysian atrophy (DRPLA), presenting clinically as progressive myoclonic epilepsy. The action myoclonus, which severely impaired her daily life, was markedly improved by administration of piracetam, a drug reportedly useful for myoclonus of cortical origin. In our case, piracetam effectively suppressed severe subcortical myoclonus of DRPLA, suggesting that the drug may be useful in the treatment of both cortical, and subcortical myoclonus.

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