TY - JOUR
T1 - Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administration of yokukansan, A traditional Japanese medicine
AU - Iwasaki, Koh
AU - Kosaka, Kenji
AU - Mori, Hideo
AU - Okitsu, Reina
AU - Furukawa, Katsutoshi
AU - Manabe, Yuta
AU - Yoshita, Mitsuhiro
AU - Kanamori, Aya
AU - Ito, Nobuo
AU - Wada, Kenji
AU - Kitayama, Michio
AU - Horiguchi, Jun
AU - Yamaguchi, Shuhei
AU - Takayama, Shin
AU - Fukuhara, Ryuji
AU - Ouma, Shinji
AU - Nakano, Seigo
AU - Hashimoto, Mamoru
AU - Kinoshita, Toru
PY - 2012/12
Y1 - 2012/12
N2 - Background: This multicentre open-label trial examined the efficacy and safety of the traditional Japanese medicine, or Kampo medicine, yokukansan (YKS), for behavioural and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies. Methods: Sixty-three dementia with Lewy bodies patients with probable BPSD (M:W, 30:33; mean age, 78.2 ± 5.8years) were enrolled and treated with YKS for 4weeks. Results: Significant improvements in Neuropsychiatric Inventory scores (mean decrease, 12.5 points; P < 0.001) and Zarit Burden Interview-Japanese edition tests (mean decrease, 3.6 points; P= 0.024) were observed. In patients who consented to an assessment after 2weeks of treatment, a time-dependent significant improvement was observed in the Neuropsychiatric Inventory score (n= 23; mean decrease, 14.4; P < 0.001), each subscale, including delusions and hallucinations, the Zarit Burden Interview-Japanese edition (n= 22; mean decrease, 8.2; P < 0.01) and the behavioural pathology in Alzheimer's disease insomnia subscale. The Mini-Mental State Examination and the Disability Assessment for Dementia (DAD) showed no significant change. Adverse events were observed in 11 (18%) patients. Three patients (5%) discontinued YKS due to adverse reactions, namely, spasticity and exacerbation of BPSD, edema, and nausea. Hypokalaemia (<3.5mEq/L) was present in four patients (6%) at the study endpoint. Worsening of extrapyramidal symptoms was not observed. Conclusion: YKS improved BPSD in dementia with Lewy bodies patients and caregiver burden scores without deterioration in cognitive function. YKS is useful for the treatment of delusions and hallucinations in BPSD.
AB - Background: This multicentre open-label trial examined the efficacy and safety of the traditional Japanese medicine, or Kampo medicine, yokukansan (YKS), for behavioural and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies. Methods: Sixty-three dementia with Lewy bodies patients with probable BPSD (M:W, 30:33; mean age, 78.2 ± 5.8years) were enrolled and treated with YKS for 4weeks. Results: Significant improvements in Neuropsychiatric Inventory scores (mean decrease, 12.5 points; P < 0.001) and Zarit Burden Interview-Japanese edition tests (mean decrease, 3.6 points; P= 0.024) were observed. In patients who consented to an assessment after 2weeks of treatment, a time-dependent significant improvement was observed in the Neuropsychiatric Inventory score (n= 23; mean decrease, 14.4; P < 0.001), each subscale, including delusions and hallucinations, the Zarit Burden Interview-Japanese edition (n= 22; mean decrease, 8.2; P < 0.01) and the behavioural pathology in Alzheimer's disease insomnia subscale. The Mini-Mental State Examination and the Disability Assessment for Dementia (DAD) showed no significant change. Adverse events were observed in 11 (18%) patients. Three patients (5%) discontinued YKS due to adverse reactions, namely, spasticity and exacerbation of BPSD, edema, and nausea. Hypokalaemia (<3.5mEq/L) was present in four patients (6%) at the study endpoint. Worsening of extrapyramidal symptoms was not observed. Conclusion: YKS improved BPSD in dementia with Lewy bodies patients and caregiver burden scores without deterioration in cognitive function. YKS is useful for the treatment of delusions and hallucinations in BPSD.
KW - Activities of daily living (ADL)
KW - Behavioural and psychological symptoms of dementia (BPSD)
KW - Caregiver's burden
KW - Dementia with Lewy bodies (DLB)
KW - Yokukansan (Yi-Gan San)
UR - http://www.scopus.com/inward/record.url?scp=84871833395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871833395&partnerID=8YFLogxK
U2 - 10.1111/j.1479-8301.2012.00413.x
DO - 10.1111/j.1479-8301.2012.00413.x
M3 - Article
C2 - 23279145
AN - SCOPUS:84871833395
VL - 12
SP - 235
EP - 241
JO - Psychogeriatrics
JF - Psychogeriatrics
SN - 1346-3500
IS - 4
ER -