Improved visual hallucination by donepezil and occipital glucose metabolism in dementia with lewy bodies: The Osaki-Tajiri project

Masayuki Satoh, Hiroyasu Ishikawa, Kenichi Meguro, Masashi Kasuya, Hiroshi Ishii, Satoshi Yamaguchi

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Deficits in the cholinergic system are pronounced in dementia with Lewy bodies (DLB) and are more severe in patients with visual hallucinations (VHs). The aim is to identify the occipital glucose metabolism patterns by positron emission tomography (PET) and the changes following donepezil treatment. 13 DLB patients with VHs were enrolled in the study. After the first FDG-PET study, 5 mg/day donepezil was administered orally, and a second PET study was performed 3 months later. After donepezil administration, VHs disappeared completely in 6 patients, and the PET studies revealed significantly decreased glucose metabolism in the medial occipital cortex. These results suggest that VHs in DLB were associated with impaired glucose metabolism in the medial occipital cortex. Donepezil treatment may modify regional glucose metabolism.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalEuropean Neurology
Volume64
Issue number6
DOIs
Publication statusPublished - 2010 Dec

Keywords

  • Dementia with Lewy bodies
  • Positron emission tomography
  • Regional cerebral metabolic rates of glucose
  • Visual hallucinations

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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