Improved therapeutic efficacy in cardiomyocyte transplantation for myocardial infarction with release system of basic fibroblast growth factor

Masaya Yamamoto, Yutaka Sakakibara, Kazunobu Nishimura, Masashi Komeda, Yasuhiko Tabata

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Several studies have demonstrated that cell transplantation was effective for the therapy of myocardial infarction. However, little care has been taken for the blood supply indispensable to cell transplantation. This study is an investigation to evaluate the feasibility of in advance angiogenesis by gelatin microspheres incorporating basic fibroblast growth factor (bFGF) for the transplantation therapy of cardiomyocytes with an ischemic cardiomyopathy model. Rats with myocardial infarction received the intramuscular injection of culture medium (Control), or that containing fetal cardiomyocytes (TX) or gelatin microspheres incorporating bFGF (FGF), and gelatin microspheres incorporating bFGF plus fetal cardiomyocytes 1 week later (FGF-TX). The left ventricle (LV) function of rat hearts was assessed by echocardiography and cardiac catheterization 4 weeks later. The LV maximum time-varying elastance was significantly higher in the FGF-TX group than in other groups. The combination of bFGF-induced angiogenesis and cardiomyocyte transplantation is a promising procedure to improve the LV function in rats with myocardial infarction.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalArtificial Organs
Volume27
Issue number2
DOIs
Publication statusPublished - 2003 Feb 1

Keywords

  • Basic fibroblast growth factor
  • Biodegradable gelatin microspheres
  • Cardiac infarction therapy
  • Cardiomyocyte transplantation
  • Controlled release
  • Prevascularization

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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