Improved synthesis of pure [18F]fluoro-compounds for PET studies from bromo-compounds

Toshihiro Takahashi, Takashi Mizuno, Tatsuo Ido, Ren Iwata, Ken Ichi Watanabe

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    For preparing [18F]labeled compounds free from bromo-compounds for PET (positron emission tomography) studies, we propose the following two processes in which no separation is needed between the fluoro-compound and bromo-compound: (1) the bromo-compound is first converted into O-tosylate, which is then [18F]fluorinated; and (2) after [18F] fluorination of the bromo-compound, its excess is converted into an easily separable compound, e.g., phthalimide-compound. Direct tosylation with silver tosylate was effected in 65-85% yield for most commercial bromo-compounds, and with potassium phthalimide, the bromo-compounds in cold run were converted easily into phthalimide-compounds in 84-90% yield.

    Original languageEnglish
    Pages (from-to)557-566
    Number of pages10
    JournalApplied Radiation and Isotopes
    Volume58
    Issue number5
    DOIs
    Publication statusPublished - 2003 May 1

    Keywords

    • Bromo-compound
    • O-tosyl-compound
    • Potassium phthalimide-compound, PET study
    • Silver tosylate
    • [F]fluoro-compound

    ASJC Scopus subject areas

    • Radiation

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