Improved synthesis of pure [18F]fluoro-compounds for PET studies from bromo-compounds

Toshihiro Takahashi, Takashi Mizuno, Tatsuo Ido, Ren Iwata, Ken Ichi Watanabe

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

For preparing [18F]labeled compounds free from bromo-compounds for PET (positron emission tomography) studies, we propose the following two processes in which no separation is needed between the fluoro-compound and bromo-compound: (1) the bromo-compound is first converted into O-tosylate, which is then [18F]fluorinated; and (2) after [18F] fluorination of the bromo-compound, its excess is converted into an easily separable compound, e.g., phthalimide-compound. Direct tosylation with silver tosylate was effected in 65-85% yield for most commercial bromo-compounds, and with potassium phthalimide, the bromo-compounds in cold run were converted easily into phthalimide-compounds in 84-90% yield.

Original languageEnglish
Pages (from-to)557-566
Number of pages10
JournalApplied Radiation and Isotopes
Volume58
Issue number5
DOIs
Publication statusPublished - 2003 May
Externally publishedYes

Keywords

  • Bromo-compound
  • O-tosyl-compound
  • Potassium phthalimide-compound, PET study
  • Silver tosylate
  • [F]fluoro-compound

ASJC Scopus subject areas

  • Radiation

Fingerprint

Dive into the research topics of 'Improved synthesis of pure [18F]fluoro-compounds for PET studies from bromo-compounds'. Together they form a unique fingerprint.

Cite this