Improved preparation of l-[Methyl-11C]methionine by on-line [11C]methylation

Ken Ichiro Mizuno; Shigeki Yamazaki; Ren Iwata; Claudio Pascali; Tatsuo Ido

doi:10.1016/0969-8043(93)90152-Z

Improved preparation of l-[Methyl-¹¹C]methionine by on-line [¹¹C]methylation

Ken Ichiro Mizuno, Shigeki Yamazaki, Ren Iwata, Claudio Pascali, Tatsuo Ido

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

On-line [¹¹C]methylation using [¹¹C]methyl iodide has been successfully applied to the preparation of l-[methyl-¹¹C]-methionine (¹¹C-Met). [¹¹C]Methyl iodide is first trapped in a short column that contains Porapak Q and l-homocysteine thiolactone coated on inert support. The column is then charged with NaOH dissolved in a mixture of ethanol and water to cause the [¹¹C]methylation. The present method can provide practically pure ¹¹C-Met in radiochemical yield of over 98%. The whole procedure including the sterilization of final product has been completely automated for routine PET use.

Original language	English
Pages (from-to)	788-790
Number of pages	3
Journal	Applied Radiation and Isotopes
Volume	44
Issue number	4
DOIs	https://doi.org/10.1016/0969-8043(93)90152-Z
Publication status	Published - 1993 Apr

ASJC Scopus subject areas

Radiation

Access to Document

10.1016/0969-8043(93)90152-Z

Cite this

@article{f82568a3d0494c4cb9ca7ec62ba6cf01,

title = "Improved preparation of l-[Methyl-11C]methionine by on-line [11C]methylation",

abstract = "On-line [11C]methylation using [11C]methyl iodide has been successfully applied to the preparation of l-[methyl-11C]-methionine (11C-Met). [11C]Methyl iodide is first trapped in a short column that contains Porapak Q and l-homocysteine thiolactone coated on inert support. The column is then charged with NaOH dissolved in a mixture of ethanol and water to cause the [11C]methylation. The present method can provide practically pure 11C-Met in radiochemical yield of over 98%. The whole procedure including the sterilization of final product has been completely automated for routine PET use.",

author = "Mizuno, {Ken Ichiro} and Shigeki Yamazaki and Ren Iwata and Claudio Pascali and Tatsuo Ido",

year = "1993",

month = apr,

doi = "10.1016/0969-8043(93)90152-Z",

language = "English",

volume = "44",

pages = "788--790",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Improved preparation of l-[Methyl-11C]methionine by on-line [11C]methylation

AU - Mizuno, Ken Ichiro

AU - Yamazaki, Shigeki

AU - Iwata, Ren

AU - Pascali, Claudio

AU - Ido, Tatsuo

PY - 1993/4

Y1 - 1993/4

N2 - On-line [11C]methylation using [11C]methyl iodide has been successfully applied to the preparation of l-[methyl-11C]-methionine (11C-Met). [11C]Methyl iodide is first trapped in a short column that contains Porapak Q and l-homocysteine thiolactone coated on inert support. The column is then charged with NaOH dissolved in a mixture of ethanol and water to cause the [11C]methylation. The present method can provide practically pure 11C-Met in radiochemical yield of over 98%. The whole procedure including the sterilization of final product has been completely automated for routine PET use.

AB - On-line [11C]methylation using [11C]methyl iodide has been successfully applied to the preparation of l-[methyl-11C]-methionine (11C-Met). [11C]Methyl iodide is first trapped in a short column that contains Porapak Q and l-homocysteine thiolactone coated on inert support. The column is then charged with NaOH dissolved in a mixture of ethanol and water to cause the [11C]methylation. The present method can provide practically pure 11C-Met in radiochemical yield of over 98%. The whole procedure including the sterilization of final product has been completely automated for routine PET use.

UR - http://www.scopus.com/inward/record.url?scp=0027416553&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027416553&partnerID=8YFLogxK

U2 - 10.1016/0969-8043(93)90152-Z

DO - 10.1016/0969-8043(93)90152-Z

M3 - Article

AN - SCOPUS:0027416553

SN - 0969-8043

VL - 44

SP - 788

EP - 790

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 4

ER -

Improved preparation of l-[Methyl-¹¹C]methionine by on-line [¹¹C]methylation

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this