Implications of radiation microdosimetry for accelerator-based boron neutron capture therapy: a radiobiological perspective

Hisanori Fukunaga, Yusuke Matsuya, Koichi Tokuuye, Motoko Omura

Research output: Contribution to journalArticlepeer-review

Abstract

Boron neutron capture therapy (BNCT) has great potential to selectively destroy cancer cells while sparing surrounding normal cells. The basic concept of BNCT was developed in the 1930s, but it has not yet been commonly used in clinical practice, even though there is now a large number of experimental and translational studies demonstrating its marked therapeutic potential. With the development of neutron accelerators that can be installed in medical institutions, accelerator-based BNCT is expected to become available at several medical institutes around the world in the near future. In this commentary, from the point of view of radiation microdosimetry, we discuss the biological effects of BNCT, especially the underlying mechanisms of compound biological effectiveness. Radiobiological perspectives provide insight into the effectiveness of BNCT in creating a synergy effect in the field of clinical oncology.

Original languageEnglish
Number of pages1
JournalThe British journal of radiology
Volume93
Issue number1111
DOIs
Publication statusPublished - 2020 Jul 1

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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