Implanted octacalcium phosphate is more resorbable than β-tricalcium phosphate and hydroxyapatite

S. Kamakura, Y. Sasano, T. Shimizu, K. Hatori, O. Suzuki, M. Kagayama, K. Motegi

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)

Abstract

Our previous studies have suggested that synthetic octacalcium phosphate (OCP) could be resorbed and replaced by newly formed bone if implanted in rat skull defects. We hypothesized that the implanted OCP is more resorbable than other commonly used bone graft substitutes of calcium phosphate compounds, such as hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). To test the hypothesis, the present study was designed to compare histomorphometrically resorption of the implanted OCP, HA, and β-TCP, which were kept in the experimental cranial defect of rats for a long term. A full thickness of standardized trephine defect was made in the rat parietal bone, and the same volume of granules of OCP, HA, and β-TCP were implanted into the defect. Five specimens of each group were fixed 6 months after implantation. The percentage of remaining implants (r-Imp%) and newly formed bone (n-Bone%) in the defect was analyzed histomorphometrically. The statistical analysis showed that the r-Imp% of OCP was significantly lower than that of HA and β-TCP. In contrast, the n-Bone% of OCP was significantly higher than that of HA and β-TCP. The present study has shown that the implanted OCP in the rat cranial defect is more resorbable than the implanted β-TCP and HA, whereas the implanted OCP enhances bone formation more than the implanted β-TCP and HA.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of Biomedical Materials Research
Volume59
Issue number1
DOIs
Publication statusPublished - 2002 Jan 1

Keywords

  • Bone defect
  • Bone repair
  • Hydroxyapatite
  • Octacalcium phosphate
  • β-tricalcium phosphate

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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