Impedance Sensing of Biological Processes in Mammalian Cells

Lamya Ghenim, Hirokazu Kaji, Matsuhiko Nishizawa, Xavier Gidrol

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cellular impedance biosensors offer an alternative to conventional analytical techniques with potential advantages over optical methods of high speed, accuracy, sensitivity, non-invasiveness, and ease of direct computer analysis. We first review the original examples of impedimetric sensing where there were several tens or hundreds of cells on the electrodes. Recent works have dealt with single cells. We will highlight impedance sensing for cells grown on electrodes, as this method allows the study of the motion of mammalian cells in real time and in conditions as close as possible to their in vivo environments. Working at alternating current of low frequencies, it is possible to probe intrinsic properties of the cells and their interaction with substrates. In some cases, electrical measurements have been shown to be sensitive to changes in cell properties that are not visible optically. Possible applications may be relevant to a wide range of subjects, such as wound healing, mitosis and pharmacological apoptosis.

Original languageEnglish
Title of host publicationIntegrated Biomaterials for Biomedical Technology
PublisherJohn Wiley and Sons
Pages293-308
Number of pages16
ISBN (Print)9781118423851
DOIs
Publication statusPublished - 2012 Aug 17

Keywords

  • Biosensor
  • Cell motility
  • Electrical sensing
  • Impedance sensing
  • Mitosis
  • Single cell

ASJC Scopus subject areas

  • Dentistry(all)

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