Impairment of an event-related potential correlate of memory in schizophrenia: Effects of immediate and delayed word repetition

Kazunori Matumoto, Hiroo Matsuoka, H. Yamazaki, H. Sakai, T. Kato, N. Miura, M. Nakamura, K. Osakabe, Hidemitsu Saito, Takashi Ueno, M. Sato

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23 Citations (Scopus)

Abstract

Objective: We investigated the nature of the memory impairment in schizophrenia using an event-related potential (ERP). Methods: Visual ERPs were recorded while 20 schizophrenics and 20 controls performed semantic categorization tasks with incidental word repetitions. Participants responded to occasional target words. Half of the non-target words were repeated immediately after initial presentation (lag 0) or after 5 intervening words (lag 5). Results: In both groups, ERPs to words at lag 0 were more positive than those to non-repeated words, though this positive-going effect was attenuated in the schizophrenics, especially around 400-500 ms. The effect at lag 5 was smaller and shorter than that at lag 0 but was comparable between groups. Attenuation of the N400 peak occurred for word repetition at lag 0 in controls but not in schizophrenics, whereas a peak increment in the late positive component induced by word repetition at both lags was observed in both groups. Conclusions: Findings indicate that patients with schizophrenia have a deficit in a brain process modulating ERP correlates of memory, when words are repeated immediately. This deficit might be related to an abnormal N400 priming effect in schizophrenia.

Original languageEnglish
Pages (from-to)662-673
Number of pages12
JournalClinical Neurophysiology
Volume112
Issue number4
DOIs
Publication statusPublished - 2001 Apr 10

Keywords

  • Late positive component
  • Memory
  • N400
  • Repetition effect
  • Schizophrenia
  • Visual event-related potential

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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    Matumoto, K., Matsuoka, H., Yamazaki, H., Sakai, H., Kato, T., Miura, N., Nakamura, M., Osakabe, K., Saito, H., Ueno, T., & Sato, M. (2001). Impairment of an event-related potential correlate of memory in schizophrenia: Effects of immediate and delayed word repetition. Clinical Neurophysiology, 112(4), 662-673. https://doi.org/10.1016/S1388-2457(01)00475-8