Impaired NK Response of Cancer Patients to IFN‐α but Not to IL‐2: Correlation with Serum Immunosuppressive Acidic Protein (IAP) and Role of Suppressor Macrophage

Hisashi Aso, Keiji Tamura, Osamu Yoshie, Takehiko Nakamura, Syuu Kikuchi, Nakao Ishida

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In vitro NK responses of cancer patients (N=21) to rIFN‐αA and rIL‐2 were examined. The serum concentration of IAP (immunosuppressive acidic protein) was determined in parallel. Five out of seven patients whose serum IAP contents were within the normal range (270 μg/ml to 470 μg/ml), had their NK activities significantly augmented by rIFN‐αA and rIL‐2. On the other hand, NK cells from ten out of fifteen patients whose serum IAP concentrations were 650 μg/ml or more, were not activated by rIFN‐αA. NK cells of these fifteen patients yet were capable of responding to rIL‐2. NK cells from cancer patients, however, became responsive to rIFN‐αA by either removal of adherent cells or treatment with indomethacin. Therefore, macrophages in PBMC of cancer patients with high serum IAP levels seem to selectively suppress NK response to rIFN‐αA by an indomethacin‐sensitive mechanisms. It was further shown that PGE2 was not the mediator of this suppression.

Original languageEnglish
Pages (from-to)1087-1097
Number of pages11
JournalMICROBIOLOGY and IMMUNOLOGY
Volume36
Issue number10
DOIs
Publication statusPublished - 1992 Oct

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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