Impaired myocardial fatty acid metabolism detected by 123I-BMIPP in patients with unstable angina pectoris: Comparison with perfusion imaging by 99mTc-sestamibi

Yasuchika Takeishi, Hiroyasu Sukekawa, Haruo Saito, Shozo Nishimura, Takayuki Shibu, Yasuhiko Sasaki, Hitonobu Tomoike

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The present study was undertaken to determine the potential diagnostic value of 123I-BMIPP scintigraphy for the detection of altered myocardial fatty acid metabolism in patients with unstable angina. Both myocardial metabolic imaging with 123I-BMIPP and perfusion imaging with 99mTcsestamibi were performed at rest in 28 patients with unstable angina in the pain-free state. The regional uptakes of 123I-BMIPP or 99mTc-sestamibi were scored semiquantitatively (0 = normal, 4 = no activity) and compared with the coronary arteriographic findings. Decreased uptakes of 123I-BMIPP were observed in 18 patients, and 11 patients had abnormal 99mTc-sestamibi images. Defect scores of 123I-BMIPP were larger than those of 99mTc-sestamibi (7.8 ± 2.1 vs. 5.2 + 1.9, p < 0.01). The sensitivity for the detection of patients with unstable angina was higher in 123I-BMIPP than in 99mTc-sestamibi (77% vs. 45%, p < 0.01). The site of the decreased 123I-BMIPP uptake corresponded to the most stenotic coronary artery lesion in all patients. Fatty acid metabolic imaging with 123I-BMIPP was more sensitive for detecting myocardial ischemia than perfusion imaging with 99mTc-sestamibi. 123I-BMIPP may be a clue to define the culprit lesion in unstable angina and be helpful to decide the best treatment and guide coronary angioplasty.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalAnnals of Nuclear Medicine
Volume9
Issue number3
DOIs
Publication statusPublished - 1995 Sep
Externally publishedYes

Keywords

  • I-BMIPP
  • Tc-sestamibi
  • unstable angina

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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