Impaired myocardial accumulation of 15-(p-iodophenyl)-9-(R, S)-methyl- pentadecanoic acid in a patient with hypertrophic cardiomyopathy and exercise-induced ischemia due to vasospasm

Atsushi Doi, Tomoaki Nakata, Fumio Obara, Michifumi Kyuma, Kazufumi Tsuchihashi, Kenji Fujimori, Kazuaki Shimamoto

Research output: Contribution to journalArticle

Abstract

We encountered a patient with hypertrophic cardiomyopathy complicated with exercise-induced myocardial ischemia. Exercise-stress 99mTc- tetrofosmin imaging demonstrated reversible ischemia in the lateral wall, whereas resting fatty acid imaging with a new beta-methyl branched fatty acid analogue. I-123-15-(p-iodophenyl)-9-(R, S)-methylpentadecanoic acid (123I- 9-MPA), showed impaired uptake and accelerated washout kinetics in the inferoapical and posteroseptal walls but not in the ischemia-related region. These findings suggest that the metabolic derangement is closely related to cardiomyopathy per se rather than exercise-induced myocardial ischemia in this patient with hypertrophic cardiomyopathy and a spastic coronary lesion so that myocardial perfusion and 123I-9-MPA imagings may contribute to clarifying the etiological background of impaired myocardial fatty acid metabolism.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalAnnals of Nuclear Medicine
Volume14
Issue number1
DOIs
Publication statusPublished - 2000 Feb
Externally publishedYes

Keywords

  • Coronary vasospasm
  • Exercise-stress
  • Fatty acid imaging
  • Hypertrophic cardiomyopathy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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