Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4

Yasuaki Mohri, Shigeki Kato, Akihiro Umezawa, Ryuhei Okuyama, Katsuhiko Nishimori

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We observed that Lgr4K5 KO mice had sparse head hair and focal alopecia behind their ears, as observed in tabby (Eda) and downless (Edar) mice, which are models of the human genetic disorder hypohidrotic (anhidrotic) ectodermal dysplasia (HED). Lgr4-deficient mice showed partial impairment in hair follicle development with reduced expression of Edar, Lef1, and SAA, which were essential for hair follicle morphogenesis, in the epidermis. Immunohistochemical analysis of Lgr4-/- mice epidermis using shh antibody showed reduced numbers of hair placodes, and we also detected higher phosphorylation of Smadl/5/8, which is required to suppress normal hair follicle induction. We suspected that Lgr4 might be a novel gene class regulating the development of hair follicles.

Original languageEnglish
Pages (from-to)2235-2242
Number of pages8
JournalDevelopmental Dynamics
Volume237
Issue number8
DOIs
Publication statusPublished - 2008 Aug 1

Keywords

  • GPCR, gene deletion mice
  • GPR48
  • Hair follicle
  • LGR4

ASJC Scopus subject areas

  • Developmental Biology

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