Abstract
Mice deficient for paired immunoglobulin (Ig)-like receptor B (PIR-B) show defective regulation of receptor-mediated activation in antigen-presenting cells. Older PIR-B-/- mice had an increased number of peritoneal BI cells. Splenic PIR-B-/- B2 cells were constitutively activated and proliferated much more than those from wild-type mice upon B cell receptor ligation. T helper type 2 (TH2)-prone humoral responses were augmented in PIR-B-/- mice upon immunization with T-dependent antigens, including increased interleukin 4 and decreased interferon-γ responses, as well as enhanced IgGI and IgE production. Impaired maturation of dendritic cells (DCs), possibly due to perturbed intracellular signaling, was responsible for the skewed responses. Thus, PIR-B is critical for B cell suppression, DC maturation and for balancing THI and TH2 immune responses.
Original language | English |
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Pages (from-to) | 542-548 |
Number of pages | 7 |
Journal | Nature Immunology |
Volume | 3 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2002 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology