Impacts of activation of the mitogen-activated protein kinase pathway in pancreatic cancer

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28 Citations (Scopus)

Abstract

Pancreatic cancer is characterized by constitutive activation of the mitogen-activated protein kinase (MAPK) pathway. Mutations of KRAS or BRAF and epigenetic abrogation of DUSP6 contribute synergistically to the constitutive activation of MAPK. Active MAPK induces the expression of a variety of genes that are thought to play roles in malignant phenotypes of pancreatic cancer. By blocking the functions of such induced genes, it is possible to attenuate the malignant phenotypes. The development of drugs targeting genes downstream of MAPK may provide a novel therapeutic option for pancreatic cancer.

Original languageEnglish
Article number23
JournalFrontiers in Oncology
Volume5
Issue numberFEB
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • BRAF
  • DUSP6
  • ERK
  • KRAS
  • MKP-3
  • Mitogen-activated protein kinase
  • Pancreatic cancer
  • microRNA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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