Impact of unilateral interposition sural nerve graft on the recovery of sexual function after radical prostatectomy in Japanese men: A preliminary study

Seiichi Saito, Shunichi Namiki, Kenji Numahata, Makoto Satoh, Shigeto Ishidoya, Akihiro Ito, Haruo Nakagawa, Yasuhiro Kaiho, Takehiko Sanada, Atsushi Yamada, Yoichi Arai

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Purpose: To determine the effect of an interposition nerve graft on sexual function after radical prostatectomy. Methods: This study includes 64 patients, without hormonal therapy, who underwent a radical prostatectomy and intraoperative electrophysiological confirmation of cavernous nerve preservation. Twelve patients underwent a unilateral interposition sural nerve graft (UNG) for the resected neurovascular bundle. Twenty-one and 31 patients underwent bilateral nerve-sparing (BNS) and unilateral nerve-sparing (UNS) surgery without a nerve graft, respectively. As the age of patients was significantly younger in the UNG group than in the other groups, age-matched analysis also was conducted. Sexual function, evaluated by a self-administered questionnaire using the University of California Los Angeles-Prostate Cancer Index, was compared statistically among the three groups. Results: In the age-matched analysis, the postoperative sexual function (SXF) score of the UNG group showed an intermediate level of recovery between those of the BNS and UNS groups at 12 months and reached the same level as the score at 12 months of the BNS group at 18 months postoperatively. The difference in the SXF score between the UNG and UNS groups began to appear after 6 months postoperatively and increased steadily with time. However, the background factors, such as the baseline SXF score, the usage rate of phosphodiesterase 5 inhibitors, and the rate of comorbidities were different between the UNG and UNS groups. Conclusions: The difference of the SXF score between the UNG and UNS groups increased with time after 6 months postoperatively. However, it might be difficult at present to attribute a better recovery of the SXF score to the nerve graft because of the difference in the background factors between the groups.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalInternational Journal of Urology
Volume14
Issue number2
DOIs
Publication statusPublished - 2007 Feb

Keywords

  • Cavernous nerve-sparing
  • Quality of life
  • Radical prostatectomy
  • Sexual function
  • Sural nerve graft

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Impact of unilateral interposition sural nerve graft on the recovery of sexual function after radical prostatectomy in Japanese men: A preliminary study'. Together they form a unique fingerprint.

Cite this