Impact of physical activity on cardiovascular events in patients with chronic heart failure - A multicenter prospective cohort study

Yutaka Miura, Yoshihiro Fukumoto, Toshiro Miura, Kazunori Shimada, Masanori Asakura, Toshiaki Kadokami, Shin Ichi Ando, Satoshi Miyata, Yasuhiko Sakata, Hiroyuki Daida, Masunori Matsuzaki, Satoshi Yasuda, Masafumi Kitakaze, Hiroaki Shimokawa

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25 Citations (Scopus)

Abstract

Background: We have previously demonstrated that the prevalence of metabolic syndrome in chronic heart failure (CHF) is more than double compared with the general population in Japan. However, the impact of physical activity on cardiovascular events in CHF patients remains to be fully elucidated. Methods and Results: We performed a prospective, nationwide large-scale multicenter study of 9,178 patients with stage A/B/C/D CHF in Japan. We obtained the baseline physical activity data for 7,292 and yearly changes in physical activity data during a 3-year follow-up period for 4,353 patients. We divided the patients into high- and low-exercise groups by using the median value of physical activity in the stage A/B and C/D groups. In both groups, patients who exercised more were characterized by younger age and less advanced stage of CHF. Importantly, the baseline physical activity levels were significantly associated with all-cause death, heart failure (HF) hospitalization and other cardiovascular events (except acute myocardial infarction, stroke, HF hospitalization). Furthermore, the yearly change in physical activity level was also significantly associated with HF hospitalization and other cardiovascular events in both groups. Conclusions: The baseline level of physical activity and its yearly changes are significantly associated with all-cause death and major cardiovascular events in both stage A/B and C/D patients, suggesting that physical activity could be an important therapeutic target to improve the long-term prognosis of CHF patients.

Original languageEnglish
Pages (from-to)2963-2972
Number of pages10
JournalCirculation Journal
Volume77
Issue number12
DOIs
Publication statusPublished - 2013 Nov 29

Keywords

  • Chronic heart failure
  • Heart failure hospitalization
  • Physical activity
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Miura, Y., Fukumoto, Y., Miura, T., Shimada, K., Asakura, M., Kadokami, T., Ando, S. I., Miyata, S., Sakata, Y., Daida, H., Matsuzaki, M., Yasuda, S., Kitakaze, M., & Shimokawa, H. (2013). Impact of physical activity on cardiovascular events in patients with chronic heart failure - A multicenter prospective cohort study. Circulation Journal, 77(12), 2963-2972. https://doi.org/10.1253/circj.CJ-13-0746