Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: A multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery

Kazuhisa Uchiyama, Masakazu Yamamoto, Hiroki Yamaue, Shun Ichi Ariizumi, Taku Aoki, Norihiro Kokudo, Tomoki Ebata, Masato Nagino, Masayuki Ohtsuka, Masaru Miyazaki, Eiichi Tanaka, Satoshi Kondo, Takahiro Uenishi, Shoji Kubo, Hiroshi Yoshida, Michiaki Unno, Satoru Imura, Mitsuo Shimada, Masaki Ueno, Tadahiro Takada

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Abstract

Background/purpose: The aim of this study was to clarify the prognostic factors of intrahepatic cholangiocarcinoma (ICC) following hepatectomy and to examine the impact of lymph node metastasis on survival. This study was therefore carried out as a Project Study of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Methods: Three hundred and forty-one patients who underwent hepatectomy for ICC between 1995 and 2004 at the 9 institutions of the Medical University Hospitals were analyzed retrospectively. Multivariate regression analyses and a Kaplan-Meyer analysis were performed to identify prognostic factors. Results: Pathological lymph node metastasis was one of the significant factors affecting overall survival (hazard ratio 2.10, p < 0.001) based on the multivariate analysis. Among the patients who underwent extended lymphadenectomy beyond the hepatoduodenal ligament, the median survival of 121 patients with nodal involvement was 12.2 months. Only seven patients with nodal involvement have survived for more than 4 years. Conclusions: In the present study, preoperative carbohydrate antigen (CA) 19-9, intrahepatic metastasis, and nodal involvement were the significant independent predictors of poor prognosis by multivariate analysis. Further prospective studies may thus be needed to confirm these findings, because this study has a limitation in that it was a retrospective study with multicenter data collection.

Original languageEnglish
Pages (from-to)443-452
Number of pages10
JournalJournal of Hepato-Biliary-Pancreatic Sciences
Volume18
Issue number3
DOIs
Publication statusPublished - 2011 May

Keywords

  • CA19-9
  • Extended lymph node dissection
  • Intrahepatic metastasis
  • Lymph node metastasis
  • Overall survival
  • Surgical margin

ASJC Scopus subject areas

  • Medicine(all)

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    Uchiyama, K., Yamamoto, M., Yamaue, H., Ariizumi, S. I., Aoki, T., Kokudo, N., Ebata, T., Nagino, M., Ohtsuka, M., Miyazaki, M., Tanaka, E., Kondo, S., Uenishi, T., Kubo, S., Yoshida, H., Unno, M., Imura, S., Shimada, M., Ueno, M., & Takada, T. (2011). Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: A multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. Journal of Hepato-Biliary-Pancreatic Sciences, 18(3), 443-452. https://doi.org/10.1007/s00534-010-0349-2