TY - JOUR
T1 - Impact of nocturia on bone fracture and mortality in older individuals
T2 - A Japanese longitudinal cohort study
AU - Nakagawa, Haruo
AU - Niu, Kaijun
AU - Hozawa, Atsushi
AU - Ikeda, Yoshihiro
AU - Kaiho, Yasuhiro
AU - Ohmori-Matsuda, Kaori
AU - Nakaya, Naoki
AU - Kuriyama, Shinichi
AU - Ebihara, Satoru
AU - Nagatomi, Ryoichi
AU - Tsuji, Ichiro
AU - Arai, Yoichi
PY - 2010/10
Y1 - 2010/10
N2 - Purpose: We evaluated the association of nocturia with fracture and death in a large, community based sample of Japanese individuals 70 years old or older. Materials and Methods: The baseline in this population based study was determined in 2003 by an extensive health interview with each participant. In this study we followed 784 individuals with a mean ± SD age of 76.0 ± 4.6 years (range 70 to 97). Information on mortality and fracture during the study period was provided by the National Health Insurance system and details on fractures were collected from medical records. We compared the risk of bone fracture and death with or without nocturia in a multivariate Cox proportional hazard model. Results: Nocturia (2 or greater voids per night) was present in 359 of the 784 participants (45.7%). Fracture was observed in 41 cases, including 32 fall related cases. For all fractures and fall related fractures with nocturia the HR was 2.01 (95% CI 1.043.87) and 2.20 (95% CI 1.044.68, each p = 0.04). Death occurred in 53 cases. The mortality rate in individuals with nocturia was significantly higher than in those without nocturia. For mortality in patients with nocturia the age-gender adjusted HR was 1.91 (95% CI 1.073.43, p = 0.03). Even when further adjusted for diabetes, smoking status, history of coronary disease, renal disease and stroke, tranquilizers, hypnotics and diuretics, the positive relationship was unchanged (HR 1.98, 95% CI 1.093.59, p = 0.03). Conclusions: During a 5-year observation period elderly individuals with nocturia were at greater risk for fracture and death than those without nocturia.
AB - Purpose: We evaluated the association of nocturia with fracture and death in a large, community based sample of Japanese individuals 70 years old or older. Materials and Methods: The baseline in this population based study was determined in 2003 by an extensive health interview with each participant. In this study we followed 784 individuals with a mean ± SD age of 76.0 ± 4.6 years (range 70 to 97). Information on mortality and fracture during the study period was provided by the National Health Insurance system and details on fractures were collected from medical records. We compared the risk of bone fracture and death with or without nocturia in a multivariate Cox proportional hazard model. Results: Nocturia (2 or greater voids per night) was present in 359 of the 784 participants (45.7%). Fracture was observed in 41 cases, including 32 fall related cases. For all fractures and fall related fractures with nocturia the HR was 2.01 (95% CI 1.043.87) and 2.20 (95% CI 1.044.68, each p = 0.04). Death occurred in 53 cases. The mortality rate in individuals with nocturia was significantly higher than in those without nocturia. For mortality in patients with nocturia the age-gender adjusted HR was 1.91 (95% CI 1.073.43, p = 0.03). Even when further adjusted for diabetes, smoking status, history of coronary disease, renal disease and stroke, tranquilizers, hypnotics and diuretics, the positive relationship was unchanged (HR 1.98, 95% CI 1.093.59, p = 0.03). Conclusions: During a 5-year observation period elderly individuals with nocturia were at greater risk for fracture and death than those without nocturia.
KW - aged
KW - fractures, bone
KW - mortality
KW - nocturia
KW - urinary bladder
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U2 - 10.1016/j.juro.2010.05.093
DO - 10.1016/j.juro.2010.05.093
M3 - Article
C2 - 20727545
AN - SCOPUS:77956501284
VL - 184
SP - 1413
EP - 1418
JO - Journal of Urology
JF - Journal of Urology
SN - 0022-5347
IS - 4
ER -