TY - JOUR
T1 - Impact of image-based scatter correction for 123IMP-SPECT and SPM analysis
AU - Shidahara, Miho
AU - Watabe, Hiroshi
AU - Kim, Kyeong Min
AU - Kawatsu, Shoji
AU - Kato, Rikio
AU - Kato, Takashi
AU - Iida, Hidehiro
AU - Ito, Kengo
PY - 2004/8/1
Y1 - 2004/8/1
N2 - Recently, techniques for converting site-specific normal databases to other databases have been required for SPECT image statistical analysis. To implement scatter correction, we developed an image conversion technique named image-based scatter correction (IBSC). Furthermore, we evaluated the applicability of IBSC for SPM analysis. SPECT studies were performed on 28 normal volunteers and 10 patients with Alzheimer's disease (AD) using 123I-IMP. Two sets of scatter uncorrected images, IACμb, and a corrected image by TEW, ITEW, were reconstructed with attenuation correction using Chang's method. Scatter corrected images by IBSC, IIBSC, were generated from IACμb. Normal databases of IACμb, ITEW and IIBSC were compared by SPM analysis. The Z-score (=(mean−AD)/S.D.) of ITEW was compared with that of IACμb. Significant differences (p<0.05) between normal databases of IACμb and ITEW observed at the global posterior cingulate and precuneus regions almost disappeared when ITEW and IIBSC were compared. The Z-score at the posterior cingulate by ITEW was increased compared with that of IACμb. We conclude that for SPM analysis of IMP-SPECT, IBSC can convert a normal database of scatter uncorrected images into corrected images, which is equivalent to correction by a conventional TEW method. Scatter correction may improve the ability to detect AD.
AB - Recently, techniques for converting site-specific normal databases to other databases have been required for SPECT image statistical analysis. To implement scatter correction, we developed an image conversion technique named image-based scatter correction (IBSC). Furthermore, we evaluated the applicability of IBSC for SPM analysis. SPECT studies were performed on 28 normal volunteers and 10 patients with Alzheimer's disease (AD) using 123I-IMP. Two sets of scatter uncorrected images, IACμb, and a corrected image by TEW, ITEW, were reconstructed with attenuation correction using Chang's method. Scatter corrected images by IBSC, IIBSC, were generated from IACμb. Normal databases of IACμb, ITEW and IIBSC were compared by SPM analysis. The Z-score (=(mean−AD)/S.D.) of ITEW was compared with that of IACμb. Significant differences (p<0.05) between normal databases of IACμb and ITEW observed at the global posterior cingulate and precuneus regions almost disappeared when ITEW and IIBSC were compared. The Z-score at the posterior cingulate by ITEW was increased compared with that of IACμb. We conclude that for SPM analysis of IMP-SPECT, IBSC can convert a normal database of scatter uncorrected images into corrected images, which is equivalent to correction by a conventional TEW method. Scatter correction may improve the ability to detect AD.
KW - I-IMP
KW - Regional cerebral blood flow
KW - Scatter correction
KW - Single photon emission computed tomography
KW - statistical analysis
UR - http://www.scopus.com/inward/record.url?scp=85023028148&partnerID=8YFLogxK
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U2 - 10.1016/j.ics.2004.04.027
DO - 10.1016/j.ics.2004.04.027
M3 - Article
AN - SCOPUS:85023028148
VL - 1265
SP - 84
EP - 88
JO - International Congress Series
JF - International Congress Series
SN - 0531-5131
IS - C
ER -