Impact of fatty acid-binding proteins in α-synuclein-induced mitochondrial injury in synucleinopathy

An Cheng, Wenbin Jia, Ichiro Kawahata, Kohji Fukunaga

Research output: Contribution to journalArticlepeer-review

Abstract

Synucleinopathies are diverse diseases with motor and cognitive dysfunction due to progressive neuronal loss or demyelination, due to oligodendrocyte loss in the brain. While the etiology of neurodegenerative disorders (NDDs) is likely multifactorial, mitochondrial injury is one of the most vital factors in neuronal loss and oligodendrocyte dysfunction, especially in Parkinson’s disease, dementia with Lewy body, multiple system atrophy, and Krabbe disease. In recent years, the abnormal accumulation of highly neurotoxic α-synuclein in the mitochondrial membrane, which leads to mitochondrial dysfunction, was well studied. Furthermore, fatty acid-binding proteins (FABPs), which are members of a superfamily and are essential in fatty acid trafficking, were reported to trigger α-synuclein oligomerization in neurons and glial cells and to target the mitochondrial outer membrane, thereby causing mitochondrial loss. Here, we provide an updated overview of recent findings on FABP and α-synuclein interactions and mitochondrial injury in NDDs.

Original languageEnglish
Article number560
JournalBiomedicines
Volume9
Issue number5
DOIs
Publication statusPublished - 2021

Keywords

  • Fatty acid-binding proteins
  • Mitochondria
  • Neurodegenerative disorders
  • α-synuclein

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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