TY - JOUR
T1 - Impact of biochemical failure on long-term clinical outcome after radical prostatectomy for prostate cancer in Japan
AU - Egawa, S.
AU - Matsui, Y.
AU - Matsumoto, K.
AU - Suyama, K.
AU - Arai, Y.
AU - Kuwao, S.
AU - Baba, S.
N1 - Funding Information:
*Correspondence: S Egawa, Department of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. E-mail: s-egpro@jcom.home.ne.jp Supported in part by a grant from the Ministry of Health and Welfare of Japan (11-10) and the Foundation for Promotion of Cancer Research in Japan. Received 18 December 2003; revised 15 February 2004; accepted 25 February 2004
PY - 2004
Y1 - 2004
N2 - Detailed information is needed to understand the impact of biochemical failure (bF) on long-term outcome after definitive therapy for prostate cancer. In all, 223 consecutive men treated with radical retropubic prostatectomy were followed and long-term clinical outcome was investigated. Pathological examination revealed more locally advanced tumors in this study compared with the typical cohorts seen in the Western series. The Cox proportional hazards model indicates pretreatment prostate-specific antigen levels and risk group stratification to be a significant predictors for bF (P < 0.05), but not for overall survival. Seminal vesicle involvement was a significant predictor of systemic progression, cancer death and overall survival (P < 0.05). Positive surgical margin and bF were also found to be independent predictors of overall survival (P < 0.05). In contrast to reports from Western countries, this study found a significant correlation between bF after radical prostatectomy and overall survival. This may reflect years-later detection of prostate cancer in Japan compared with Western series. Biochemical failure may ultimately be translated into decreased overall survival after sufficient follow-up.
AB - Detailed information is needed to understand the impact of biochemical failure (bF) on long-term outcome after definitive therapy for prostate cancer. In all, 223 consecutive men treated with radical retropubic prostatectomy were followed and long-term clinical outcome was investigated. Pathological examination revealed more locally advanced tumors in this study compared with the typical cohorts seen in the Western series. The Cox proportional hazards model indicates pretreatment prostate-specific antigen levels and risk group stratification to be a significant predictors for bF (P < 0.05), but not for overall survival. Seminal vesicle involvement was a significant predictor of systemic progression, cancer death and overall survival (P < 0.05). Positive surgical margin and bF were also found to be independent predictors of overall survival (P < 0.05). In contrast to reports from Western countries, this study found a significant correlation between bF after radical prostatectomy and overall survival. This may reflect years-later detection of prostate cancer in Japan compared with Western series. Biochemical failure may ultimately be translated into decreased overall survival after sufficient follow-up.
KW - Biochemical failure
KW - Overall survival
KW - Prostate-specific antigen
KW - Radical prostatectomy
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U2 - 10.1038/sj.pcan.4500715
DO - 10.1038/sj.pcan.4500715
M3 - Article
C2 - 15175664
AN - SCOPUS:3142753526
VL - 7
SP - 152
EP - 157
JO - Prostate Cancer and Prostatic Diseases
JF - Prostate Cancer and Prostatic Diseases
SN - 1365-7852
IS - 2
ER -
