Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors

Satoru Tokuyama; Seiichi Saito; Toshiko Takahashi; Chikara Ohyama; I. T.O. Akihiro; Satoru Kanto; Makoto Satoh; Senji Hoshi; Mareyuki Endoh; Yoichi Arai

doi:10.3892/or.10.5.1097

Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors

Satoru Tokuyama, Seiichi Saito, Toshiko Takahashi, Chikara Ohyama, I. T.O. Akihiro, Satoru Kanto, Makoto Satoh, Senji Hoshi, Mareyuki Endoh, Yoichi Arai

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Stage-specific embryonic antigen-4 (SSEA-4) is expressed in testicular germ-cell tumors (GCT) according to studies using thin-layer chromatography (TLC) immunostaining. To further understand the relationship between SSEA-4 and the histogenesis of testicular GCT, we examined the expression of SSEA-4 in 43 samples of testicular GCT either by immunohistochemical staining or by TLC immunostaining. Immunohistochemical staining detected SSEA-4 in spermatogonia from the non-tumor parts of the testis and in all of 8 samples of intratubular germ cell neoplasia unclassified (IGCNU). Immunohistochemical staining was SSEA-4 positive in all 9 seminomas, and in one yolk sac tumor and in 5 embryonal carcinomas among 9 non-seminomas. Immunostaining with TLC showed that SSEA-4 was retained in 15 of 16 seminomas and in 4 of 8 non-seminomas. These results demonstrate an antigenic link between spermatogonia, IGCNU, and testicular GCT. We suggest that SSEA-4 is associated with the histogenesis of testicular GCT.

Original language	English
Pages (from-to)	1097-1104
Number of pages	8
Journal	Oncology reports
Volume	10
Issue number	5
DOIs	https://doi.org/10.3892/or.10.5.1097
Publication status	Published - 2003 Sep

Keywords

Globo-series glycolipids
Intratubular germ cell neoplasia unclassified
Spermatogonia
Stage-specific embryonic antigen-4
Testicular germ-cell tumor

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3892/or.10.5.1097

Cite this

Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors. / Tokuyama, Satoru; Saito, Seiichi; Takahashi, Toshiko; Ohyama, Chikara; Akihiro, I. T.O.; Kanto, Satoru; Satoh, Makoto; Hoshi, Senji; Endoh, Mareyuki; Arai, Yoichi.

In: Oncology reports, Vol. 10, No. 5, 09.2003, p. 1097-1104.

Research output: Contribution to journal › Article › peer-review

Tokuyama, Satoru ; Saito, Seiichi ; Takahashi, Toshiko ; Ohyama, Chikara ; Akihiro, I. T.O. ; Kanto, Satoru ; Satoh, Makoto ; Hoshi, Senji ; Endoh, Mareyuki ; Arai, Yoichi. / Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors. In: Oncology reports. 2003 ; Vol. 10, No. 5. pp. 1097-1104.

@article{1df4d787f58944cca5c90a2d0bbd95b8,

title = "Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors",

abstract = "Stage-specific embryonic antigen-4 (SSEA-4) is expressed in testicular germ-cell tumors (GCT) according to studies using thin-layer chromatography (TLC) immunostaining. To further understand the relationship between SSEA-4 and the histogenesis of testicular GCT, we examined the expression of SSEA-4 in 43 samples of testicular GCT either by immunohistochemical staining or by TLC immunostaining. Immunohistochemical staining detected SSEA-4 in spermatogonia from the non-tumor parts of the testis and in all of 8 samples of intratubular germ cell neoplasia unclassified (IGCNU). Immunohistochemical staining was SSEA-4 positive in all 9 seminomas, and in one yolk sac tumor and in 5 embryonal carcinomas among 9 non-seminomas. Immunostaining with TLC showed that SSEA-4 was retained in 15 of 16 seminomas and in 4 of 8 non-seminomas. These results demonstrate an antigenic link between spermatogonia, IGCNU, and testicular GCT. We suggest that SSEA-4 is associated with the histogenesis of testicular GCT.",

keywords = "Globo-series glycolipids, Intratubular germ cell neoplasia unclassified, Spermatogonia, Stage-specific embryonic antigen-4, Testicular germ-cell tumor",

author = "Satoru Tokuyama and Seiichi Saito and Toshiko Takahashi and Chikara Ohyama and Akihiro, {I. T.O.} and Satoru Kanto and Makoto Satoh and Senji Hoshi and Mareyuki Endoh and Yoichi Arai",

year = "2003",

month = sep,

doi = "10.3892/or.10.5.1097",

language = "English",

volume = "10",

pages = "1097--1104",

journal = "Oncology Reports",

issn = "1021-335X",

publisher = "Spandidos Publications",

number = "5",

}

TY - JOUR

T1 - Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors

AU - Tokuyama, Satoru

AU - Saito, Seiichi

AU - Takahashi, Toshiko

AU - Ohyama, Chikara

AU - Akihiro, I. T.O.

AU - Kanto, Satoru

AU - Satoh, Makoto

AU - Hoshi, Senji

AU - Endoh, Mareyuki

AU - Arai, Yoichi

PY - 2003/9

Y1 - 2003/9

N2 - Stage-specific embryonic antigen-4 (SSEA-4) is expressed in testicular germ-cell tumors (GCT) according to studies using thin-layer chromatography (TLC) immunostaining. To further understand the relationship between SSEA-4 and the histogenesis of testicular GCT, we examined the expression of SSEA-4 in 43 samples of testicular GCT either by immunohistochemical staining or by TLC immunostaining. Immunohistochemical staining detected SSEA-4 in spermatogonia from the non-tumor parts of the testis and in all of 8 samples of intratubular germ cell neoplasia unclassified (IGCNU). Immunohistochemical staining was SSEA-4 positive in all 9 seminomas, and in one yolk sac tumor and in 5 embryonal carcinomas among 9 non-seminomas. Immunostaining with TLC showed that SSEA-4 was retained in 15 of 16 seminomas and in 4 of 8 non-seminomas. These results demonstrate an antigenic link between spermatogonia, IGCNU, and testicular GCT. We suggest that SSEA-4 is associated with the histogenesis of testicular GCT.

AB - Stage-specific embryonic antigen-4 (SSEA-4) is expressed in testicular germ-cell tumors (GCT) according to studies using thin-layer chromatography (TLC) immunostaining. To further understand the relationship between SSEA-4 and the histogenesis of testicular GCT, we examined the expression of SSEA-4 in 43 samples of testicular GCT either by immunohistochemical staining or by TLC immunostaining. Immunohistochemical staining detected SSEA-4 in spermatogonia from the non-tumor parts of the testis and in all of 8 samples of intratubular germ cell neoplasia unclassified (IGCNU). Immunohistochemical staining was SSEA-4 positive in all 9 seminomas, and in one yolk sac tumor and in 5 embryonal carcinomas among 9 non-seminomas. Immunostaining with TLC showed that SSEA-4 was retained in 15 of 16 seminomas and in 4 of 8 non-seminomas. These results demonstrate an antigenic link between spermatogonia, IGCNU, and testicular GCT. We suggest that SSEA-4 is associated with the histogenesis of testicular GCT.

KW - Globo-series glycolipids

KW - Intratubular germ cell neoplasia unclassified

KW - Spermatogonia

KW - Stage-specific embryonic antigen-4

KW - Testicular germ-cell tumor

UR - http://www.scopus.com/inward/record.url?scp=2142860757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2142860757&partnerID=8YFLogxK

U2 - 10.3892/or.10.5.1097

DO - 10.3892/or.10.5.1097

M3 - Article

C2 - 12883664

AN - SCOPUS:2142860757

VL - 10

SP - 1097

EP - 1104

JO - Oncology Reports

JF - Oncology Reports

SN - 1021-335X

IS - 5

ER -

Immunostaining of stage-specific embryonic antigen-4 in intratubular germ cell neoplasia unclassified and in testicular germ-cell tumors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this