TY - JOUR
T1 - Immunolocalization of c-myc oncoprotein in mucinous and serous adenocarcinomas of the ovary
AU - Sasano, Hironobu
AU - Nagura, Hiroshi
AU - Silverberg, Steven G.
PY - 1992/5
Y1 - 1992/5
N2 - Activation of c-myc oncogene has been reported in increasing numbers of human ovarian carcinomas and appears to play a role in the biologic behavior of the neoplasms. We have studied the immunohistochemical localization of p-62c-myc, the gene product of c-myc, in 44 cases of serous and mucinous cystadenoma, adenocarcinoma of low malignant potential, and invasive adenocarcinoma, using a monoclonal antibody raised to a synthetic human p62c-myc sequence (Myc 1-6E10). Both serous and mucinous cystadenomas demonstrated a higher frequency of nuclear localization than did carcinomas, which showed much greater cytoplasmic staining, while tumors of low malignant potential showed an intermediate pattern. However, the observed differences did not reach statistical significance. No significant correlation was observed between intracellular localization patterns of p62c-myc and histologic and nuclear grades and mitotic activity in the cases of carcinoma. Great care should be taken in the interpretation of immunohistochemical analysis of oncogene products, especially when attempting to correlate the findings with biologic tumor behavior.
AB - Activation of c-myc oncogene has been reported in increasing numbers of human ovarian carcinomas and appears to play a role in the biologic behavior of the neoplasms. We have studied the immunohistochemical localization of p-62c-myc, the gene product of c-myc, in 44 cases of serous and mucinous cystadenoma, adenocarcinoma of low malignant potential, and invasive adenocarcinoma, using a monoclonal antibody raised to a synthetic human p62c-myc sequence (Myc 1-6E10). Both serous and mucinous cystadenomas demonstrated a higher frequency of nuclear localization than did carcinomas, which showed much greater cytoplasmic staining, while tumors of low malignant potential showed an intermediate pattern. However, the observed differences did not reach statistical significance. No significant correlation was observed between intracellular localization patterns of p62c-myc and histologic and nuclear grades and mitotic activity in the cases of carcinoma. Great care should be taken in the interpretation of immunohistochemical analysis of oncogene products, especially when attempting to correlate the findings with biologic tumor behavior.
KW - c-myc
KW - cancer
KW - immunohistochemistry
KW - ovary
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UR - http://www.scopus.com/inward/citedby.url?scp=0026645022&partnerID=8YFLogxK
U2 - 10.1016/0046-8177(92)90125-M
DO - 10.1016/0046-8177(92)90125-M
M3 - Article
C2 - 1314775
AN - SCOPUS:0026645022
VL - 23
SP - 491
EP - 495
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 5
ER -