Immunohistopathological and molecular genetic features of a case in which gastroibtestiinal stromal tumor recurred five times

Tsukasa Inoue, Takashi Suzuki, Kunitoshi Nakagawa, Yoshimochi Kurokawa, Susumu Satomi, Takuya Moriya, Nobuaki Sasano, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Gastrointestinal stromal tumor (GIST) is a distinct group of mesenchymal neoplasms recently shown to exhibit differentiation toward interstitial cells of Cajal. Although previous studies have shown that the clinical outcome of patients with GIST is associated with mitotic activity, the proliferation index determined by the Ki-67 labeling index, immunophenotype (CD34 and/or p53) and mutation in exon 11 of the c-kit, a definitive discrimination between benign and malignant GIST has not yet been established. We report a patient in whom malignant GIST in the abdomen recurred five times. In this case, the primary GIST and the five recurrent GIST were associated with c-kit immunoreactivity, but the mitotic index of the GIST tended to be increasingly higher with subsequent recurrences. Mutational analysis of the c-kit revealed that the primary and recurrent GIST were mutant-negative. These data indicated that 'morphologically appearing benign' tumors with lower proliferative parameters may also have the capacity of metastasis and recurrence.

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalPathology international
Volume54
Issue number3
DOIs
Publication statusPublished - 2004 Mar

Keywords

  • Gastrointestinal stromal tumor
  • Mutation
  • Proliferation index
  • c-kit gene

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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