Immunohistochemical study on tumor angiogenic factors in non-small cell lung cancer

Hirokazu Aikawa, Hiroto Takahashi, Shigefumi Fujimura, Masami Sato, Chiaki Endo, Akira Sakurada, Takashi Kondo, Tatsuo Tanita, Yuji Matsumura, Sadafumi Ono, Yasuki Saito, Motoyasu Sagawa

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Background. In order to elucidate the roles of tumor angiogenesis in lung carcinogenesis, the expression of several angiogenic factors in lung carcinoma tissues were examined. Materials and Methods. Tissue specimens from 112 cases of resected non-small cell lung cancer (NSCLC) were studied. The expressions of platelet-derived endothelial cell growth factor (PD-ECGF) and vascular endothelial growth factor (VEGF) were examined immunohistochemically. Microvessel density (MVD) was also evaluated. Results. VEGF-positive cases were observed more frequently in advanced stage lung cancers than in early cancers, and VEGF-positive tumors had higher MVD than VEGF-negative tumors, while such differences were not observed for PD-ECGF. In squamous cell carcinoma, the patients with high-MVD tumor had significantly worse survival than those with low-MVD tumor. Conclusions. Our results suggest that VEGF plays an important role in angiogenesis of lung cancers, while the contribution of PD-ECGF may be limited.

Original languageEnglish
Pages (from-to)4305-4309
Number of pages5
JournalAnticancer research
Issue number5 B
Publication statusPublished - 1999


  • Angiogenesis
  • Lung cancer
  • Microvessel density
  • VEGF

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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