Immunohistochemical study on the pathogenesis of drug-induced gingival hyperplasia

Keiichi Saito, Shiro Mori, Masaki Iwakura, Naoko Tanda, Seizaburo Sakamoto, Kyoko Ikawa, Takeyoshi Koseki

Research output: Contribution to journalReview articlepeer-review

Abstract

Immunohistochemical localization of TGFβ, bFGF and their receptors, c-myc and bcl-2 oncoproteins, and Ki-67 antigen was examined in 9 hyperplastic gingival tissues induced by nifedipine and phenytoin, and 5 non-hyperplastic control tissues to elucidate the pathogenesis of drug-induced gingival hyperplasia. The results of our present study indicate that the overexpression of TGFβ, bFGF is related to the morphogenesis of hyperplastic lamina propria, whereas the intensive immunolocalization of c-myc and bcl-2 oncoprotein contributes to that of hyperplastic gingival epithelia. The tissue growth features of hyperplastic gingivae which were shown by Ki-67 antigen expression seem to reflect the involvement of these ligands in the pathogenesis of drug-induced gingival hyperplasia.

Original languageEnglish
Pages (from-to)85-86
Number of pages2
JournalInternational Congress Series
Volume1284
DOIs
Publication statusPublished - 2005 Sep

Keywords

  • Gingival hyperplasia
  • KI-67
  • TGFβ
  • bFGF
  • bcl-2
  • c-myc

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Immunohistochemical study on the pathogenesis of drug-induced gingival hyperplasia'. Together they form a unique fingerprint.

Cite this