Immunohistochemical study of Bcl-2 protein, apoptosis and p53 protein expression in non-small cell lung cancer

Yan Chen, Yasuki Saito, Masami Sato, Motoyasu Sagatva, Hiroto Takahashi, Chiaki Endo, Akira Sakurada, Hirokazu Aikaiva, Katsuo Usuda, Shigefumi Fujimura

Research output: Contribution to journalArticlepeer-review


We investigated the expression of Bcl-2 protein, apoptosis and p53 protein immunohistochemically in resected non-small cell lung cancer. Bcl-2 protein was expressed in 24% of squamous cell carcinoma (SQ), 17% of adenocarcinoma (AD), and 17% of large cell carcinoma (LA). The staining with Apop Tag was positive in 35% of SQ, 27% of AD, and 25% of LA. p53 protein was detected in 42% of SQ, 20% of AD, and 42% of LA. In squamous cell carcinoma, the expressions of Bcl-2 protein, Apop Tag and p53 protein were higher than in other histologie types. The survival rate of patients with resected Bcl-2-positive carcinoma was higher than those with resected Bcl-2-negative carcinoma (95.5% vs. 81.4%). The expression of Bcl-2 protein was higher in stage I lung carcinoma than in others. The expression of p53 protein was higher in Bcl-2 protein positive tumors than in Bcl-2 protein negative tumors ( p=0.06). The expression of Apop Tag was significantly higher in Bcl-2 protein and p53 protein-positive tumors than in Bcl-2 protein-negative and/or p53 protein-negative tumors (p=0.018).

Original languageEnglish
Pages (from-to)785-790
Number of pages6
JournalJapanese Journal of Lung Cancer
Issue number6
Publication statusPublished - 1996
Externally publishedYes


  • Apoptosis
  • Bcl-2 protein
  • Immunohistological stainings
  • Non-small cell lung cancer
  • P53 protein

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine


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