Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain

Akinori Takeda, Takeshi Yasuda, Toshio Miyata, Keiko Mizuno, Mei Li, Sakae Yoneyama, Katsunori Horie, Kenji Maeda, Sobue Gen Sobue

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains without dementia, but not in young brains less than 17 years of age. Extraneuroperikaryal AGE deposits were also detected in the neuropil of AD and aged brains. The extra-neuroperikaryal AGE deposits markedly increased in AD brains as compared to aged brains. These AGE-positive deposits in the neuropil were not related to the senile plaque identified by anti-β amyloid protein antibody. These findings suggest a potential link of AGE accumulation in the central nervous system to the aging process of neurons and the degenerating process of AD neurons.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 1996 Dec 27
Externally publishedYes


  • Alzheimer's disease
  • advanced glycation end products
  • aging
  • neuron
  • β-amyloid protein

ASJC Scopus subject areas

  • Neuroscience(all)


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