Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain

Akinori Takeda; Takeshi Yasuda; Toshio Miyata; Keiko Mizuno; Mei Li; Sakae Yoneyama; Katsunori Horie; Kenji Maeda; Sobue Gen Sobue

doi:10.1016/S0304-3940(96)13275-4

Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain

Akinori Takeda, Takeshi Yasuda, Toshio Miyata, Keiko Mizuno, Mei Li, Sakae Yoneyama, Katsunori Horie, Kenji Maeda, Sobue Gen Sobue

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains without dementia, but not in young brains less than 17 years of age. Extraneuroperikaryal AGE deposits were also detected in the neuropil of AD and aged brains. The extra-neuroperikaryal AGE deposits markedly increased in AD brains as compared to aged brains. These AGE-positive deposits in the neuropil were not related to the senile plaque identified by anti-β amyloid protein antibody. These findings suggest a potential link of AGE accumulation in the central nervous system to the aging process of neurons and the degenerating process of AD neurons.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Neuroscience Letters
Volume	221
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(96)13275-4
Publication status	Published - 1996 Dec 27
Externally published	Yes

Keywords

Alzheimer's disease
advanced glycation end products
aging
neuron
β-amyloid protein

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(96)13275-4

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title = "Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain",

abstract = "Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains without dementia, but not in young brains less than 17 years of age. Extraneuroperikaryal AGE deposits were also detected in the neuropil of AD and aged brains. The extra-neuroperikaryal AGE deposits markedly increased in AD brains as compared to aged brains. These AGE-positive deposits in the neuropil were not related to the senile plaque identified by anti-β amyloid protein antibody. These findings suggest a potential link of AGE accumulation in the central nervous system to the aging process of neurons and the degenerating process of AD neurons.",

keywords = "Alzheimer's disease, advanced glycation end products, aging, neuron, β-amyloid protein",

author = "Akinori Takeda and Takeshi Yasuda and Toshio Miyata and Keiko Mizuno and Mei Li and Sakae Yoneyama and Katsunori Horie and Kenji Maeda and {Gen Sobue}, Sobue",

year = "1996",

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doi = "10.1016/S0304-3940(96)13275-4",

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volume = "221",

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AU - Takeda, Akinori

AU - Yasuda, Takeshi

AU - Miyata, Toshio

AU - Mizuno, Keiko

AU - Li, Mei

AU - Yoneyama, Sakae

AU - Horie, Katsunori

AU - Maeda, Kenji

AU - Gen Sobue, Sobue

PY - 1996/12/27

Y1 - 1996/12/27

N2 - Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains without dementia, but not in young brains less than 17 years of age. Extraneuroperikaryal AGE deposits were also detected in the neuropil of AD and aged brains. The extra-neuroperikaryal AGE deposits markedly increased in AD brains as compared to aged brains. These AGE-positive deposits in the neuropil were not related to the senile plaque identified by anti-β amyloid protein antibody. These findings suggest a potential link of AGE accumulation in the central nervous system to the aging process of neurons and the degenerating process of AD neurons.

AB - Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains without dementia, but not in young brains less than 17 years of age. Extraneuroperikaryal AGE deposits were also detected in the neuropil of AD and aged brains. The extra-neuroperikaryal AGE deposits markedly increased in AD brains as compared to aged brains. These AGE-positive deposits in the neuropil were not related to the senile plaque identified by anti-β amyloid protein antibody. These findings suggest a potential link of AGE accumulation in the central nervous system to the aging process of neurons and the degenerating process of AD neurons.

KW - Alzheimer's disease

KW - advanced glycation end products

KW - aging

KW - neuron

KW - β-amyloid protein

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JF - Neuroscience Letters

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ER -

Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain

Abstract

Keywords

ASJC Scopus subject areas

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