TY - JOUR
T1 - Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas
AU - Suzui, Hiroshi
AU - Takahashi, Jun A.
AU - Fukumoto, Manabu
AU - Hashimoto, Nobuo
AU - Itoh, Nobuyuki
AU - Hatanaka, Masakazu
AU - Kikuchi, Haruhiko
PY - 1994/4/25
Y1 - 1994/4/25
N2 - Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (χ2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.
AB - Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (χ2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.
KW - Basic fibroblast growth factor
KW - Fibroblast growth factor receptor I
KW - Immunohistochemistry
KW - Pituitary adenoma
KW - Proliferating cellular nucleolar antigen
KW - RT-PCR
KW - S-100
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U2 - 10.1016/0304-3940(94)90637-8
DO - 10.1016/0304-3940(94)90637-8
M3 - Article
C2 - 7916136
AN - SCOPUS:0028210974
VL - 171
SP - 192
EP - 196
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -