Immunohistochemical study for basic fibroblast growth factor and fibroblast growth factor receptor I in pituitary adenomas

Hiroshi Suzui, Jun A. Takahashi, Manabu Fukumoto, Nobuo Hashimoto, Nobuyuki Itoh, Masakazu Hatanaka, Haruhiko Kikuchi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (χ2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalNeuroscience Letters
Volume171
Issue number1-2
DOIs
Publication statusPublished - 1994 Apr 25

Keywords

  • Basic fibroblast growth factor
  • Fibroblast growth factor receptor I
  • Immunohistochemistry
  • Pituitary adenoma
  • Proliferating cellular nucleolar antigen
  • RT-PCR
  • S-100

ASJC Scopus subject areas

  • Neuroscience(all)

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