Immunohistochemical similarities between lichen sclerosus et atrophicus and morphea: A case study

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Abstract

Both morphea and lichen sclerosus et atrophicus (LSA) are connective tissue diseases that mainly affect the skin. A recent report suggested that a substantial portion of morphea coexists with LSA. In this report, we describe a case of LSA on the abdomen accompanied by morphea; we employed immunohistochemical staining for periostin as well as MMP-7 and MMP-28, both of which are reported to facilitate fibrosis in the development of various organs, including skin. To our knowledge, this is first English language paper that demonstrates the immunohistochemical staining of periostin, MMP-7 and MMP-28 for morphea and LSA. Our present case might suggest possible mechanisms for the coexistence of two different sclerotic skin disorders.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalCase Reports in Dermatology
Volume7
Issue number1
DOIs
Publication statusPublished - 2015 May 22

Keywords

  • Lichen sclerosus et atrophicus
  • MMP-28
  • MMP-7
  • Morphea
  • Periostin

ASJC Scopus subject areas

  • Dermatology

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