TY - JOUR
T1 - Immunohistochemical localization of inducible nitric oxide synthase in synovial tissue of human temporomandibular joints with internal derangement
AU - Homma, Hidetaka
AU - Takahashi, Tetsu
AU - Seki, Hiroshi
AU - Ohtani, Maki
AU - Kondoh, Toshirou
AU - Fukuda, Masayuki
PY - 2001/1/1
Y1 - 2001/1/1
N2 - The expression and distribution of inducible nitric oxide synthase (iNOS) was examined in 12 samples of human temporomandibular joint (TMJ) with internal derangement (ID)and four control specimens. In the diseased joints, strong or definite iNOS reactivity was expressed in synovial lining and endothelial cells; weaker activity was present in synovial fibroblasts. In contrast, although there was weak expression of iNOS in synovial fibroblasts and endothelial cells in the two control specimens, there was no iNOS staining in the synovial lining cell layers. This original report that iNOS is expressed in the synovial tissue of the temporomandibular joint indicates that nitric oxide is produced locally at least in the synovial lining in these joints when affected by internal derangement.
AB - The expression and distribution of inducible nitric oxide synthase (iNOS) was examined in 12 samples of human temporomandibular joint (TMJ) with internal derangement (ID)and four control specimens. In the diseased joints, strong or definite iNOS reactivity was expressed in synovial lining and endothelial cells; weaker activity was present in synovial fibroblasts. In contrast, although there was weak expression of iNOS in synovial fibroblasts and endothelial cells in the two control specimens, there was no iNOS staining in the synovial lining cell layers. This original report that iNOS is expressed in the synovial tissue of the temporomandibular joint indicates that nitric oxide is produced locally at least in the synovial lining in these joints when affected by internal derangement.
KW - Immunohistochemistry
KW - Inducible nitric oxide synthase
KW - Nitric oxide
KW - Synovial lining
KW - Synovial tissue
KW - Temporomandibular joint
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U2 - 10.1016/S0003-9969(00)00086-8
DO - 10.1016/S0003-9969(00)00086-8
M3 - Article
C2 - 11163600
AN - SCOPUS:0035156555
VL - 46
SP - 93
EP - 97
JO - Archives of Oral Biology
JF - Archives of Oral Biology
SN - 0003-9969
IS - 1
ER -