Immunohistochemical localization of inducible nitric oxide synthase in synovial tissue of human temporomandibular joints with internal derangement

Hidetaka Homma, Tetsu Takahashi, Hiroshi Seki, Maki Ohtani, Toshirou Kondoh, Masayuki Fukuda

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The expression and distribution of inducible nitric oxide synthase (iNOS) was examined in 12 samples of human temporomandibular joint (TMJ) with internal derangement (ID)and four control specimens. In the diseased joints, strong or definite iNOS reactivity was expressed in synovial lining and endothelial cells; weaker activity was present in synovial fibroblasts. In contrast, although there was weak expression of iNOS in synovial fibroblasts and endothelial cells in the two control specimens, there was no iNOS staining in the synovial lining cell layers. This original report that iNOS is expressed in the synovial tissue of the temporomandibular joint indicates that nitric oxide is produced locally at least in the synovial lining in these joints when affected by internal derangement.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalArchives of Oral Biology
Volume46
Issue number1
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

Keywords

  • Immunohistochemistry
  • Inducible nitric oxide synthase
  • Nitric oxide
  • Synovial lining
  • Synovial tissue
  • Temporomandibular joint

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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